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Art. -Nr.: HY-111159

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CP-467688

CP-467688 is an orally active retinotoxic agent. CP-467688 induces increased lysosome volume, phagocytosis inhibition and autophagy inhibition in retinal cells. CP-467688 is applicable to the research of retinopathy.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 909576-25-6
Formel: C₂₇H₂₇ClF₃N₃O₃
Molecular Weight:533.97

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CP-467688 Chemical Structure

CAS. Nr.: 909576-25-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

CP-467688 (1.2-100.0 mM; 24 h) induces concentration-dependent lysosomal volume expansion in ARPE-19 cells^[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits the phagocytic function of ARPE-19 cells^[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits autophagic flux in ARPE-19 cells, with the peak punctate LC3 fluorescence intensity being approximately 5 times that of the control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

ARPE-19
Concentration:

1.5, 1.2, 3.1, 3.7, 11.1, 33.3, 100.0 mM
Incubation Time:

24 h
Result:

Induced a concentration-dependent increase in punctate LC3 fluorescence intensity relative to vehicle control, with peak activity reaching approximately 5-fold greater than control.
Triggered a > 2-fold increase in LC3 intensity at multiple tested concentrations.

In Vivo

CP-467688 (100-500 mg/kg; p.o.; daily; 7-14 days) induces retinal toxicity in male Sprague-Dawley rats, as evidenced by vacuolization and disruption of the RPE layer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male)^[1]
Dosage:

100 mg/kg; 500 mg/kg
Administration:

p.o.; daily; 7-14 days
Result:

Induced retinal lesions characterized by disrupted retinal pigmented epithelium (RPE) with multiple, round-to-oval vacuoles of variable size in RPE cytoplasm.

Chemical Information

CAS. Nr. 909576-25-6
Molecular Weight 533.97
Formel C₂₇H₂₇ClF₃N₃O₃
SMILES

O=C(OC)NCCN1CC2=C(C=C(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)C=C2)CC1.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Khoh-Reiter S, et al. Contribution of membrane trafficking perturbation to retinal toxicity. Toxicol Sci. 2015 Jun;145(2):383-95.
[Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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