country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-119238

Copy Link Print Information

CRL-42872

CRL-42872 is an orally active, highly bioavailable Gp IIb/IIIa platelet receptor inhibitor. CRL-42872 inhibits the binding of fibrinogen to the Gp IIb/IIIa receptor, thereby suppressing collagen-induced platelet aggregation. CRL-42872 is widely used in thrombosis-related studies.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 256385-24-7
Formel: C₂₂H₂₇ClN₆O₆S
Molecular Weight:539.00

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

CRL-42872 Chemical Structure

CAS. Nr.: 256385-24-7

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

CRL-42872 (1.5×10^-8 M - 7×10^-5 M; 3 minutes) potently inhibits collagen-induced aggregation of guinea pig platelets with an IC₅₀ of 9.4×10^-8 M^[1].
CRL-42872 (10^-8 M - 5×10^-5 M; 3 minutes) inhibits collagen-induced aggregation of human platelets with an IC₅₀ of 1.2×10^-7 M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CRL-42872 (10 mg/kg; p.o.; single dose) achieves inhibition of collagen-induced guinea pig platelet aggregation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Dunkin-Hartley (male, ~330 g)^[1]
Dosage:

10 mg/kg
Administration:

p.o.; single dose
Result:

Inhibited collagen-induced platelet aggregation by 68% at 1 hour post-administration.
Inhibited collagen-induced platelet aggregation by 64% at 2 hours post-administration.

Chemical Information

CAS. Nr. 256385-24-7
Molecular Weight 539.00
Formel C₂₂H₂₇ClN₆O₆S
SMILES

O=C1CN(C2=CC=C(C=C2)C(N)=N)CCN1CC(NC[C@@H](C(O)=O)NS(=O)(C3=CC=CC=C3)=O)=O.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yue C, et al. Substituted piperazinones and their therapeutic uses: U.S. Patent 6,335,337[P]. 2002-1-1.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

CRL-42872