CVN14
CVN14 is a potent, selective and brain-penetrant CD38 inhibitor with human IC50 19 nM, mouse IC50 2.4 nM. CVN14 binds uncompetitively to form a complex with CD38 and ADPR, and inhibits CD38 enzymatic activity. CVN14 can be used for the research of neurodegenerative diseases.
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- CAS. Nr.: 2925663-26-7
- Formel: C17H21F3N6O
- Molecular Weight:382.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
CVN14 potently inhibits human CD38 with an IC50 of 19 nM and mouse CD38 with an IC50 of 2.4 nM[1].
CVN14 potently inhibits human CD38 activity in CHO-hCD38 cells with an IC50 of 19 nM[1].
CVN14 binds tightly to human CD38 with a Kd of 3.6 nM and a long dissociation half-life of 143 min[1].
CVN14 has favorable in vitro permeability across MDR1-MDCK cell monolayers with an efflux ratio of 0.90[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2925663-26-7
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Molecular Weight 382.38
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Formel C17H21F3N6O
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SMILES
FC(F)(F)CN[C@H](CC1)CC[C@@H]1NC(C2=CC(C)=NC(N3C=NC=C3)=N2)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
CVN14 Related Classifications
HY-181543 Related Classifications
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