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Art. -Nr.: HY-144801A

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DDO-02005

DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC₅₀ value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl₂-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine.

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CAS. Nr.: 1186049-44-4
Formel: C₂₁H₂₇Cl₂N₃O₂
Molecular Weight:424.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

DDO-02005 Chemical Structure

CAS. Nr.: 1186049-44-4

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC₅₀: 0.72 μM (Kv1.5 potassium channel)^[1]

In Vivo

DDO-02005 (0.1, 1, 3, 9 mg/kg; IV, single dosage) effectively combat the arrhythmogenic toxicity of aconitine in rats^[1].
Pharmacokinetic Parameters of DDO-02005 in Sprague-Dawley rats^[1].

	IV (1 mg/kg)	PO (1.25 mg/kg)
t_1/2 (h)	3.23 ± 1.07	6.25 ± 2.40
C_max (μg/L)	90.23 ± 28.83	1.27 ± 0.40
AUC_0-t (μg/L·h)	178.42 ± 39.33	4.41 ± 0.69
CL (L/h/kg)	5.83 ± 1.44	36.51 ± 2.54

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1186049-44-4
Molecular Weight 424.36
Formel C₂₁H₂₇Cl₂N₃O₂
SMILES

COC1=CC=C(C=C1)CNC2CCN(CC3=NC4=CC=CC=C4O3)CC2.[H]Cl.[H]Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhao L, et al. Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors. J Enzyme Inhib Med Chem. 2022;37(1):462-471. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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