Art. -Nr.: HY-N2500

Deoxypodophyllotoxin

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Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis. Deoxypodophyllotoxin induces cell autophagy and apoptosis. Deoxypodophyllotoxin evokes increase of intracellular Ca²⁺ concentrations in DRG neurons.

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Reinheit: 99.52%
CAS. Nr.: 19186-35-7
Formel: C₂₂H₂₂O₇
Molecular Weight:398.41

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Deoxypodophyllotoxin Chemical Structure

CAS. Nr.: 19186-35-7

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Deoxypodophyllotoxin (DPT), a derivative of podophyllotoxin, is a lignan with potent antimitotic, anti-inflammatory and antiviral properties isolated from Anthriscus sylvestris. Deoxypodophyllotoxin, targets the microtubule, has a major impact in oncology not only as anti-mitotics but also as potent inhibitors of angiogenesis^[1]. Deoxypodophyllotoxin induces cell autophagy and apoptosis^[2]. Deoxypodophyllotoxin evokes increase of intracellular Ca²⁺ concentrations in DRG neurons^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	4.3 μg/mL Compound: 9	Cytotoxicity against human A431 cells Cytotoxicity against human A431 cells	[PMID: 8277312]
A549	ED₅₀	15.5 nM Compound: Deoxypodophylltoxin (DPT)	Cytotoxic activity against human lung cancer A549 cell line was determined Cytotoxic activity against human lung cancer A549 cell line was determined	[PMID: 11844709]
A549	ED₅₀	23 nM Compound: DPT (1)	In vitro cytotoxicity against A549 (human lung carcinoma) cell line. In vitro cytotoxicity against A549 (human lung carcinoma) cell line.	[PMID: 12419378]
A549	ED₅₀	0.012 μg/mL Compound: DPT	Cytotoxicity in A549 (human carcinoma) cell line. Cytotoxicity in A549 (human carcinoma) cell line.	[PMID: 12873481]
A549	IC₅₀	0.47 μM Compound: 2, DPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 21733601]
A549	IC₅₀	1.38 μM Compound: 8, DPT	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22041063]
A549	IC₅₀	1.38 μM Compound: 9, DPT	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 22244588]
A549	IC₅₀	0.004 μg/mL Compound: 10	Antiproliferative activity against human A549 cells assessed as inhibition of cell viability by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell viability by MTT assay	[PMID: 32223924]
A549	IC₅₀	<0.006 μM Compound: 2 (Deoxypodophyllotoxin)	Antineoplastic activity against A-549 (human lung carcinoma) cell line. Antineoplastic activity against A-549 (human lung carcinoma) cell line.	10.1016/0960-894X(95)00432-S
BC1 cell line	ED₅₀	0.001 μg/mL Compound: 9	Cytotoxicity against human BC1 cells Cytotoxicity against human BC1 cells	[PMID: 8277312]
BXPC-3	ED₅₀	0.0029 μg/mL Compound: 2	Anticancer activity against human BxPC3 cells after 48 hrs by SRB assay Anticancer activity against human BxPC3 cells after 48 hrs by SRB assay	[PMID: 14987061]
BXPC-3	GI₅₀	0.00044 μg/mL Compound: 1	Growth inhibition of human BxPC3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human BxPC3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
BXPC-3	GI₅₀	0.44 ng/mL Compound: 1	Growth inhibition of human BxPC3 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human BxPC3 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
Col2	ED₅₀	0.01 μg/mL Compound: 9	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 8277312]
CV-1	IC₅₀	0.025 μM Compound: 7	Antiviral activity against HSV1 infected in monkey CV-1 cells assessed as inhibition of plaque formation Antiviral activity against HSV1 infected in monkey CV-1 cells assessed as inhibition of plaque formation	[PMID: 9834179]
CV-1	IC₅₀	0.006 μM Compound: 2 (Deoxypodophyllotoxin)	Antineoplastic activity against CV-1 (monkey kidney fibroblast) cell line. Antineoplastic activity against CV-1 (monkey kidney fibroblast) cell line.	10.1016/0960-894X(95)00432-S
DU-145	ED₅₀	0.0028 μg/mL Compound: 2	Anticancer activity against human DU145 cells after 48 hrs by SRB assay Anticancer activity against human DU145 cells after 48 hrs by SRB assay	[PMID: 14987061]
DU-145	GI₅₀	0.0017 μg/mL Compound: 1	Growth inhibition of human DU145 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human DU145 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
GLC4 cell line	IC₅₀	0.008 μM Compound: 23	Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on continuous incubation Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on continuous incubation	[PMID: 7783142]
GLC4 cell line	IC₅₀	0.12 μM Compound: 23	Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on 2 hr incubation Cytotoxic effect against GLC4 (human small cell lung carcinoma cell line) using the microculture tetrazolium (MTT) assay based on 2 hr incubation	[PMID: 7783142]
HCT-116	IC₅₀	14.5 nM Compound: DPT	Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells measured after 72 hrs by MTT assay	[PMID: 36471625]
HeLa	IC₅₀	0.0069 μM Compound: 7	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 21570846]
HeLa	IC₅₀	36 μM Compound: 2, DPT	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 21733601]
HeLa	IC₅₀	1.98 μM Compound: 8, DPT	Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as growth inhibition after 48 hrs by CCK-8 assay	[PMID: 22041063]
HeLa	IC₅₀	6.01 μM Compound: 9, DPT	Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells after 48 hrs by CCK-8 assay	[PMID: 22244588]
HepG2	IC₅₀	14.5 μg/mL Compound: 10	Antiproliferative activity against human HepG2 cells assessed as inhibition of cell viability by MTT assay Antiproliferative activity against human HepG2 cells assessed as inhibition of cell viability by MTT assay	[PMID: 32223924]
HL-60	IC₅₀	0.47 μM Compound: 8, DPT	Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay Cytotoxicity against human HL60 cells assessed as growth inhibition after 48 hrs by CCK-8 assay	[PMID: 22041063]
HL-60	IC₅₀	0.47 μM Compound: 9, DPT	Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay Cytotoxicity against human HL60 cells after 48 hrs by CCK-8 assay	[PMID: 22244588]
HT	ED₅₀	0.003 μg/mL Compound: 9	Cytotoxicity against human HT cells Cytotoxicity against human HT cells	[PMID: 8277312]
HT-29	IC₅₀	2.5 ng/mL Compound: Deoxypodophyllotoxin	Growth inhibition of human HT29 cells Growth inhibition of human HT29 cells	[PMID: 15332833]
HT-29	IC₅₀	16.6 nM Compound: DPT	Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells measured after 72 hrs by MTT assay	[PMID: 36471625]
HT-29	IC₅₀	0.006 μM Compound: 2 (Deoxypodophyllotoxin)	Antineoplastic activity against HT-29 (human colon carcinoma) cell line. Antineoplastic activity against HT-29 (human colon carcinoma) cell line.	10.1016/0960-894X(95)00432-S
K562	IC₅₀	16 nM Compound: DPT	Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay Antiproliferative activity against human K562 cells measured after 72 hrs by MTT assay	[PMID: 36471625]
KB	IC₅₀	0.0089 μM Compound: 7	Cytotoxicity against human KB cells after 72 hrs by MTT assay Cytotoxicity against human KB cells after 72 hrs by MTT assay	[PMID: 21570846]
KB	IC₅₀	0.003 μM Compound: Dppt	Cytotoxicity against human KB cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay Cytotoxicity against human KB cells assessed as inhibition of cell proliferation after 72 hrs by MTS assay	[PMID: 22429510]
KB	ED₅₀	0.032 μg/mL Compound: 4	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 521819]
KB	ED₅₀	0.05 μg/mL Compound: 9	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 8277312]
KB-V1	ED₅₀	0.06 μg/mL Compound: 9	Cytotoxicity against human KBV1 cells Cytotoxicity against human KBV1 cells	[PMID: 8277312]
KM-20L2	ED₅₀	0.0028 μg/mL Compound: 2	Anticancer activity against human KM20L2 cells after 48 hrs by SRB assay Anticancer activity against human KM20L2 cells after 48 hrs by SRB assay	[PMID: 14987061]
KM-20L2	GI₅₀	0.0014 μg/mL Compound: 1	Growth inhibition of human KM20L2 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human KM20L2 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
LNCaP	IC₅₀	0.03 μM Compound: 4	Cytotoxicity against androgen sensitive human LNCaP cells Cytotoxicity against androgen sensitive human LNCaP cells	[PMID: 17256902]
LNCaP	ED₅₀	0.01 μg/mL Compound: 9	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 8277312]
Lu1	ED₅₀	0.002 μg/mL Compound: 9	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 8277312]
MCF7	ED₅₀	11.7 nM Compound: Deoxypodophylltoxin (DPT)	Cytotoxic activity against human breast cancer MCF-7 cell line was determined Cytotoxic activity against human breast cancer MCF-7 cell line was determined	[PMID: 11844709]
MCF7	ED₅₀	11 nM Compound: DPT (1)	In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line. In vitro cytotoxicity against MCF-7 (human breast carcinoma) cell line.	[PMID: 12419378]
MCF7	ED₅₀	0.0021 μg/mL Compound: 2	Anticancer activity against human MCF7 cells after 48 hrs by SRB assay Anticancer activity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 14987061]
MCF7	GI₅₀	0.0027 μg/mL Compound: 1	Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human MCF7 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
MCF7	IC₅₀	6 nM Compound: DPT	Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay	[PMID: 36471625]
MDA-MB-231	IC₅₀	0.07 μg/mL Compound: 10	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability by MTT assay	[PMID: 32223924]
NCI-H460	ED₅₀	0.0027 μg/mL Compound: 2	Anticancer activity against human NCI-H460 cells after 48 hrs by SRB assay Anticancer activity against human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 14987061]
NCI-H460	GI₅₀	0.0018 μg/mL Compound: 1	Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
P388	ED₅₀	0.0023 μg/mL Compound: 2	Anticancer activity against mouse P388 cells after 48 hrs Anticancer activity against mouse P388 cells after 48 hrs	[PMID: 14987061]
P388	IC₅₀	2.5 ng/mL Compound: Deoxypodophyllotoxin	Growth inhibition of mouse P388 cells Growth inhibition of mouse P388 cells	[PMID: 15332833]
P388	ED₅₀	0.029 μg/mL Compound: 1	Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of mouse P388 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
P388	ED₅₀	0.002 μg/mL Compound: 9	Cytotoxicity in mouse P388 cells Cytotoxicity in mouse P388 cells	[PMID: 8277312]
P388	IC₅₀	0.01 μM Compound: 2 (Deoxypodophyllotoxin)	Antineoplastic activity against P-388 (murine leukemia) cell line. Antineoplastic activity against P-388 (murine leukemia) cell line.	10.1016/0960-894X(95)00432-S
PC-3	IC₅₀	0.032 μM Compound: 4	Cytotoxicity against androgen-independent human PC3 cells Cytotoxicity against androgen-independent human PC3 cells	[PMID: 17256902]
PC-3	IC₅₀	0.018 μM Compound: 8	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	[PMID: 27214307]
SF-268	ED₅₀	0.0033 μg/mL Compound: 2	Anticancer activity against human SF268 cells after 48 hrs by SRB assay Anticancer activity against human SF268 cells after 48 hrs by SRB assay	[PMID: 14987061]
SF-268	GI₅₀	0.00056 μg/mL Compound: 1	Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
SF-268	GI₅₀	0.56 ng/mL Compound: 1	Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay Growth inhibition of human SF268 cells measured after 48 hrs by sulforhodamine B assay	[PMID: 26938998]
SiHa	IC₅₀	10.2 μM Compound: 2, DPT	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	[PMID: 21733601]
SiHa	IC₅₀	6.01 μM Compound: 8, DPT	Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay Cytotoxicity against human SiHa cells assessed as growth inhibition after 48 hrs by MTT assay	[PMID: 22041063]
SiHa	IC₅₀	1.98 μM Compound: 9, DPT	Cytotoxicity against human SiHa cells after 48 hrs by MTT assay Cytotoxicity against human SiHa cells after 48 hrs by MTT assay	[PMID: 22244588]
SK-MEL-2	ED₅₀	8.4 nM Compound: Deoxypodophylltoxin (DPT)	Cytotoxic activity against human melanoma SK-MEL-2 was determined Cytotoxic activity against human melanoma SK-MEL-2 was determined	[PMID: 11844709]
SK-MEL-2	ED₅₀	14 nM Compound: DPT (1)	In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line. In vitro cytotoxicity against SK-MEL-2 (human melanoma) cell line.	[PMID: 12419378]
SK-MEL-2	ED₅₀	0.009 μg/mL Compound: DPT	Cytotoxicity in SK-MEL-2 (human melanoma) cell line. Cytotoxicity in SK-MEL-2 (human melanoma) cell line.	[PMID: 12873481]
U-373MG ATCC	ED₅₀	0.001 μg/mL Compound: 9	Cytotoxicity against human U373 cells Cytotoxicity against human U373 cells	[PMID: 8277312]
ZR-75-1	ED₅₀	2 μg/mL Compound: 9	Cytotoxicity against human ZR-75-1 cells Cytotoxicity against human ZR-75-1 cells	[PMID: 8277312]

In Vitro

Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively^[1].
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) treats SGC-7901 cells arrested in G2/M phase in time- and dose- dependent manners^[1].
Deoxypodophyllotoxin (25-75 nM; 6-48 hours) results in a remarkably time- and dose-dependent decrease in Cdc2 and Cdc25C expression levels and increases cyclin B1 within 6h, decreases PARP, Bcl-2 and caspase-3 activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

SGC-7901 cells
Concentration:

25, 50, 75 nM
Incubation Time:

6, 12, 24, 48 hours
Result:

Induced apoptosis in SGC-7901 Cells.

Cell Cycle Analysis^[1]

Cell Line:

SGC-7901 cells
Concentration:

25, 50, 75 nM
Incubation Time:

6, 12, 24, 48 hours
Result:

Induced G2/M cell cycle arrest in SGC-7901 Cells

Western Blot Analysis^[1]

Cell Line:

SGC-7901 cells
Concentration:

25, 50, 75 nM
Incubation Time:

6, 12, 24, 48 hours
Result:

Altered the expression of cyclin B1, Cdc2,Cdc25C, p-PARP, Bcl-2 and p-caspase-3 proteins.

In Vivo

Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Xenograft model of gastric cancer in nude mice with SGC-7901 cells^[1]
Dosage:

5, 10, and 20 mg/kg
Administration:

Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days
Result:

Inhibited the growth of gastric cancer tumors.

Chemical Information

CAS. Nr. 19186-35-7
Appearance Solid
Molecular Weight 398.41
Formel C₂₂H₂₂O₇
Color White to off-white
SMILES

O=C1[C@]2([H])[C@H](C3=CC(OC)=C(OC)C(OC)=C3)C4=CC(OCO5)=C5C=C4C[C@@]2([H])CO1
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
- Plants
- Umbelliferae
- Plants
- other families
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (251.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5100 mL

12.5499 mL

25.0998 mL

5 mM

0.5020 mL

2.5100 mL

5.0200 mL

10 mM

0.2510 mL

1.2550 mL

2.5100 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (6.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang YR, et al. Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in SGC-7901 cells and inhibits tumor growth in vivo. Molecules. 2015 Jan 20;20(1):1661-75. [Content Brief]

[2]. Kim SH, et al. Deoxypodophyllotoxin induces cytoprotective autophagy against apoptosis via inhibition of PI3K/AKT/mTOR pathway in osteosarcoma U2OS cells. Pharmacol Rep. 2017 Oct;69(5):878-884. [Content Brief]

[3]. Xu P, et al. Pharmacological effect of deoxypodophyllotoxin: a medicinal agent of plant origin, on mammalian neurons. Neurotoxicology. 2010 Dec;31(6):680-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5100 mL	12.5499 mL	25.0998 mL	62.7494 mL
	5 mM	0.5020 mL	2.5100 mL	5.0200 mL	12.5499 mL
	10 mM	0.2510 mL	1.2550 mL	2.5100 mL	6.2749 mL
	15 mM	0.1673 mL	0.8367 mL	1.6733 mL	4.1833 mL
	20 mM	0.1255 mL	0.6275 mL	1.2550 mL	3.1375 mL
	25 mM	0.1004 mL	0.5020 mL	1.0040 mL	2.5100 mL
	30 mM	0.0837 mL	0.4183 mL	0.8367 mL	2.0916 mL
	40 mM	0.0627 mL	0.3137 mL	0.6275 mL	1.5687 mL
	50 mM	0.0502 mL	0.2510 mL	0.5020 mL	1.2550 mL
	60 mM	0.0418 mL	0.2092 mL	0.4183 mL	1.0458 mL
	80 mM	0.0314 mL	0.1569 mL	0.3137 mL	0.7844 mL
	100 mM	0.0251 mL	0.1255 mL	0.2510 mL	0.6275 mL

Keywords

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Menge:

Deoxypodophyllotoxin

Anti-Infection Compound Library

Apoptosis Compound Library

Cell Cycle/DNA Damage Compound Library

Natural Product Library

Anti-Cancer Compound Library

Antiviral Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Anti-Cardiovascular Disease Compound Library

Cytoskeleton Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Lung Cancer Compound Library

Anti-Obesity Compound Library

Anti-Cancer Natural Product Library

Protein-protein Interaction Inhibitor Library

Antiviral Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Miao Ethnicity Medicine Compound Library

PBCRBS Traditional Chinese Medicine Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Biotoxin Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

High-Efficiency Gene Editing Compound Library

Mass Spectrometry Natural Product Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Deoxypodophyllotoxin Related Classifications

HY-N2500 Related Classifications