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Art. -Nr.: HY-117582

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Elvucitabine

Elvucitabine is an L-nucleoside analogue. Elvucitabine is a potent nucleoside reverse transcriptase (RT) inhibitor. Elvucitabine can be used in research of viral infection.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 181785-84-2
Formel: C₉H₁₀FN₃O₃
Molecular Weight:227.19

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Elvucitabine Chemical Structure

CAS. Nr.: 181785-84-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Elvucitabine is an L-nucleoside analogue. Elvucitabine is a potent nucleoside reverse transcriptase (RT) inhibitor. Elvucitabine can be used in research of viral infection^[1].

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	>200 μM Compound: 1	In vitro inhibitory activity against growth of HIV infected B16 cell line In vitro inhibitory activity against growth of HIV infected B16 cell line	[PMID: 9873711]
CCRF-CEM	ED₅₀	>100 μM Compound: 2	In vitro concentration required to decrease 50% of mitochondrial DNA content in CEM cells In vitro concentration required to decrease 50% of mitochondrial DNA content in CEM cells	[PMID: 8627596]
CCRF-CEM	ED₅₀	7 μM Compound: 2	In vitro concentration required to inhibit 50% of CEM cell growth In vitro concentration required to inhibit 50% of CEM cell growth	[PMID: 8627596]
CCRF-CEM	IC₅₀	>100 μM Compound: RVT	Cytotoxicity was determined in CEM cells, relative to RVT Cytotoxicity was determined in CEM cells, relative to RVT	[PMID: 15081000]
CCRF-CEM	IC₅₀	0.46 μM Compound: beta-L-D4FC	Tested in vitro for anticancer activity against CEM cells Tested in vitro for anticancer activity against CEM cells	[PMID: 10072683]
CCRF-CEM	IC₅₀	13 μM Compound: 4	Tested for cytotoxicity in human T-cell lymphoblastic leukemia cell line (CEM) Tested for cytotoxicity in human T-cell lymphoblastic leukemia cell line (CEM)	[PMID: 9871628]
CCRF-CEM	IC₅₀	24 μM Compound: 1	In vitro inhibitory activity against growth of HIV infected CEM cells combined with murine CTLL-2T lymphoblast cell line In vitro inhibitory activity against growth of HIV infected CEM cells combined with murine CTLL-2T lymphoblast cell line	[PMID: 9873711]
CCRF-CEM	IC₅₀	6.5 μM Compound: 1	In vitro inhibitory activity against growth of HIV infected CEM cell line In vitro inhibitory activity against growth of HIV infected CEM cell line	[PMID: 9873711]
DLD-1	IC₅₀	>200 μM Compound: 1	In vitro inhibitory activity against growth of HIV infected DLD-1 cell line In vitro inhibitory activity against growth of HIV infected DLD-1 cell line	[PMID: 9873711]
HepG2	EC₅₀	17 nM Compound: 4	Tested for effective concentration against HBV treated with drug every 3 days for 9 days using human hepatoblastoma cell line HepG2 2.2.15 Tested for effective concentration against HBV treated with drug every 3 days for 9 days using human hepatoblastoma cell line HepG2 2.2.15	[PMID: 9871628]
HepG2	ED₅₀	2 nM Compound: 2	Concentration required to inhibit 50% of extracellular circular replication of HBV DNA using 2215 cell line Concentration required to inhibit 50% of extracellular circular replication of HBV DNA using 2215 cell line	[PMID: 8627596]
HepG2	ED₅₀	2 nM Compound: 2	Concentration required to inhibit 50% of intracellular circular replication of HBV DNA using 2215 cell line Concentration required to inhibit 50% of intracellular circular replication of HBV DNA using 2215 cell line	[PMID: 8627596]
HepG2	IC₅₀	>200 μM Compound: 1	In vitro inhibitory activity against growth of HIV infected HepG2 cell line In vitro inhibitory activity against growth of HIV infected HepG2 cell line	[PMID: 9873711]
HepG2	IC₅₀	118 μM Compound: beta-L-D4FC	Tested in vitro for anticancer activity against HepG2 cells Tested in vitro for anticancer activity against HepG2 cells	[PMID: 10072683]
LNCaP	IC₅₀	55.2 μM Compound: beta-L-D4FC	Tested in vitro for anticancer activity against LNCaP cells Tested in vitro for anticancer activity against LNCaP cells	[PMID: 10072683]
MCF7	IC₅₀	82.8 μM Compound: beta-L-D4FC	Tested in vitro for anticancer activity against MCF-7 cells Tested in vitro for anticancer activity against MCF-7 cells	[PMID: 10072683]
MT2	ED₅₀	0.09 μM Compound: 2	Concentration required to inhibit 50% of HIV activity in MT-2 cells Concentration required to inhibit 50% of HIV activity in MT-2 cells	[PMID: 8627596]
MT2	IC₅₀	9 μM Compound: 1	In vitro inhibitory activity against growth of HIV infected MT-2/IIIB cell line In vitro inhibitory activity against growth of HIV infected MT-2/IIIB cell line	[PMID: 9873711]
PC-3	IC₅₀	>100 μM Compound: beta-L-D4FC	Tested in vitro for anticancer activity against PC-3 cells Tested in vitro for anticancer activity against PC-3 cells	[PMID: 10072683]
Rat1	IC₅₀	>200 μM Compound: 1	In vitro inhibitory activity against growth of HIV infected Rat-1 cell line In vitro inhibitory activity against growth of HIV infected Rat-1 cell line	[PMID: 9873711]
SK-MEL-28	IC₅₀	>100 μM Compound: beta-L-D4FC	Tested in vitro for anticancer activity against SK-MEL-28 cells Tested in vitro for anticancer activity against SK-MEL-28 cells	[PMID: 10072683]
SK-MES-1	IC₅₀	99.1 μM Compound: beta-L-D4FC	Tested in vitro for anticancer activity against SK-MES-1 cells Tested in vitro for anticancer activity against SK-MES-1 cells	[PMID: 10072683]
Vero	IC₅₀	>100 μM Compound: RVT	Cytotoxicity was determined in Vero cells, relative to RVT Cytotoxicity was determined in Vero cells, relative to RVT	[PMID: 15081000]
Vero	IC₅₀	9.4 μM Compound: beta-L-D4FC	Tested in vitro for cytotoxicity against Vero cells Tested in vitro for cytotoxicity against Vero cells	[PMID: 10072683]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 181785-84-2
Molecular Weight 227.19
Formel C₉H₁₀FN₃O₃
SMILES

O=C1N=C(C(F)=CN1[C@H]2O[C@H](C=C2)CO)N
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Guedes AC, et, al. Microalgae as sources of high added-value compounds--a brief review of recent work. Biotechnol Prog. 2011 May-Jun;27(3):597-613. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
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Elvucitabine

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Elvucitabine Related Classifications

HY-117582 Related Classifications