ERK-IN-7
ERK-IN-7 (Example 10), an analogue of SHR2415 (HY-151367), is a potent ERK inhibitor with IC50 of 5 nM and 7 nM against ERK1 and ERK2, respectively.
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- CAS. Nr.: 2494010-63-6
- Formel: C22H20ClN7O2
- Molecular Weight:449.89
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
ERK1 5 nM (IC50) |
ERK2 7 nM (IC50) |
In Vitro
ERK-IN-7 (Example 10; 24 h) inhibits Colo205 proliferation with an IC50 of 62 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Colo205
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Concentration:
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Incubation Time:24 h
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Result:Inhibited proliferation with an IC50 of 62 nM.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57 mice[1]
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Dosage:2 mg/kg
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Administration:Intragastric administration (Pharmacokinetic Analysis)
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Result:Pharmacokinetic parameters[1]
Cmax (ng/mL) AUC (ng⋅h/mL) T1/2 (h) MRT (h) CLz/F (mL/min/kg) Vz/F (mL/kg) ERK-IN-7 (Example 10) 1023 3441 3.66 3.47 9.69 3067
Chemical Information
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CAS. Nr. 2494010-63-6
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Molecular Weight 449.89
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Formel C22H20ClN7O2
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SMILES
O=C1N2C(CN1[C@@H](C3=CC(Cl)=CC=C3)CO)=CC(C4=NC(NC5=CC=NN5C)=NC=C4)=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ERK-IN-7 Related Classifications
HY-153350 Related Classifications
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