FEMA 4774
Based on 1 Customer Validation
FEMA 4774 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer.
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- Reinheit: 99.42%
- CAS. Nr.: 1359963-68-0
- Formel: C19H25N3O4
- Molecular Weight:359.42
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
FEMA 4774 (0-50 μM) induces a dose-dependent decrease in the EC50 value of sucrose and significantly enhances the affinity of sucrose for its binding site with an α (effect of modulator on agonist affinity) value of 30 in the human sweet receptor cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
The pharmacokinetic parameters of FEMA 4774 (S9632) in Male and Female Sprague-Dawley Rats
| Route | Day | Dose (mg/kg) | Sex | Cmax (ng/mL)±SD | Tmax (hr) | t1/2 (hr) | AUC0last(ng•hr/mL) | AUC0last/dose(ng•hr/mL/mg/kg) | %F |
| iv | 1 | 1.0 | M | 2036.7±281.9 | 0.03 | 0.19 | 330.6±58 | 330.6 | - |
| F | 2625.8±679.9 | 0.03 | 0.27 | 411.9±116.3 | 411.9 | - | |||
| Oral gavage | 1 | 10 | M | 12.9±3.2 | 0.25 | 1.21 | 17.9±2.3 | 1.79 | 0.54 |
| F | 34.0±3.9 | 0.25 | 1.17 | 49.2±7.8 | 4.92 | 1.19 | |||
| 30 | M | 90.0±23.9 | 0.33 | 0.88 | 90.8±11.0 | 3.03 | 0.92 | ||
| F | 62.4±25.9 | 0.42 | 1.06 | 95.0±20.4 | 3.17 | 0.77 | |||
| 100 | M | 147.2±86.3 | 0.33 | 0.71 | 176.2±73.8 | 1.76 | 0.53 | ||
| F | 268.5±90.7 | 0.25 | 0.99 | 341.1±81.0 | 3.41 | 0.83 | |||
| Oral gavage | 7 | 10 | M | 16.2±3.6 | 0.50 | 0.84 | 48.1±33.2 | 4.81 | - |
| F | 32.7±9.7 | 0.33 | 1.17 | 58.9±25.4 | 5.89 | - | |||
| 30 | M | 74.5±16.2 | 0.33 | 0.94 | 86.0±8.7 | 2.87 | - | ||
| F | 77.1±41.7 | 0.25 | 1.39 | 106.8±8.7 | 3.56 | - | |||
| 100 | M | 117.9±15.3 | 0.25 | 0.72 | 185.3±15.3 | 1.85 | - | ||
| F | 189.7±79.5 | 0.25 | 0.89 | 278.9±79.0 | 2.79 | - | |||
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1359963-68-0
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Appearance Solid
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Molecular Weight 359.42
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Formel C19H25N3O4
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Color White to off-white
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SMILES
O=C(C1=C(C2=C(OCC(C)(C)C(NC(C)C)=O)C=CC=C2N=C1C)N)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : ≥ 41.67 mg/mL (115.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Guy Servant, et al. The function and allosteric control of the human sweet taste receptor. Adv Pharmacol. 2020;88:59-82. [Content Brief]
[2]. Amy J Arthur, et al. Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid. Toxicol Rep. 2015 Sep 3;2:1255-1264. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7823 mL | 13.9113 mL | 27.8226 mL | 69.5565 mL |
| 5 mM | 0.5565 mL | 2.7823 mL | 5.5645 mL | 13.9113 mL | |
| 10 mM | 0.2782 mL | 1.3911 mL | 2.7823 mL | 6.9557 mL | |
| 15 mM | 0.1855 mL | 0.9274 mL | 1.8548 mL | 4.6371 mL | |
| 20 mM | 0.1391 mL | 0.6956 mL | 1.3911 mL | 3.4778 mL | |
| 25 mM | 0.1113 mL | 0.5565 mL | 1.1129 mL | 2.7823 mL | |
| 30 mM | 0.0927 mL | 0.4637 mL | 0.9274 mL | 2.3186 mL | |
| 40 mM | 0.0696 mL | 0.3478 mL | 0.6956 mL | 1.7389 mL | |
| 50 mM | 0.0556 mL | 0.2782 mL | 0.5565 mL | 1.3911 mL | |
| 60 mM | 0.0464 mL | 0.2319 mL | 0.4637 mL | 1.1593 mL | |
| 80 mM | 0.0348 mL | 0.1739 mL | 0.3478 mL | 0.8695 mL | |
| 100 mM | 0.0278 mL | 0.1391 mL | 0.2782 mL | 0.6956 mL |
FEMA 4774 Related Classifications
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