FV-162
FV-162 is a potent, orally active and irreversible proteasome inhibitor. FV-162 exhibits cytotoxic to human myeloma cell lines and primary myeloma cells. FV-162 inhibits tumor growth in a myeloma xenograft mouse model. FV-162 can be used for myeloma research.
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- CAS. Nr.: 1565822-28-7
- Formel: C25H28F4N4O7S
- Molecular Weight:604.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Parmacokinetics
| Species | Dose | Route | Cmax | Tmax | AUC | F | T1/2 | CL | Vd |
|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 25 mg/kg | p.o. | 21 ng/mL | 60 min | 3117 min·ng/mL | 10 % | / | / | / |
| Mice[1] | 5 mg/kg | i.v. | 268 ng/mL | 5 min | 6633 min·ng/mL | / | 95 min | 702 mL/min/kg | 96 L/kg |
| Rat[1] | 40 mg/kg | p.o. | 615 ng/mL | 15 min | 27073 min·ng/mL | 14 % | / | / | / |
| Rat[1] | 5 mg/kg | i.v. | 392 ng/mL | 5 min | 24184 min·ng/mL | / | 68 min | 1345 mL/min/kg | 20 L/kg |
Chemical Information
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CAS. Nr. 1565822-28-7
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Molecular Weight 604.57
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Formel C25H28F4N4O7S
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SMILES
O=C(C1=CN=C(C)S1)N[C@@H](COC(F)F)C(N[C@@H](COC(F)F)C(N[C@@H](CC2=CC=CC=C2)C([C@]3(CO3)C)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
FV-162 Related Classifications
HY-117520 Related Classifications
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