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Art. -Nr.: HY-189458

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GCC-1

GCC-1 is a glycolipid. GCC-1 binds to CD1d to form a glycolipid-CD1d complex, which is presented to cellular TCR, thereby activating cells in a CD1d-dependent manner. GCC-1 induces Th1-biased cellular activation and IFN-γ production. GCC-1 can be used for research on colon adenocarcinoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₅₂H₉₃NO₁₀
Molecular Weight:892.30

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

GCC-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

CD1d

In Vitro

Innate ImmunityAdaptive Immunity

Innate Immunity

Adaptive Immunity

GCC-1 (100 nM; 2-24 h) is more efficiently presented and persists longer on the surface of DC2.4 cells than αGalCer via CD1d-mediated antigen presentation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Innate ImmunityAdaptive ImmunityCytokines & ChemokinesAnti-cancer

Innate Immunity

Adaptive Immunity

Cytokines & Chemokines

Anti-cancer

GCC-1 (i.p.; single injection) more effectively activates innate immune responses in mice and enhances the synergistic activation of NKT and NK cells^[1].

Anti-cancer

GCC-1 (1 nmol; i.v.; on days 3 and 10) induces potent antitumor activity, reducing tumor volume to approximately 1000 mm³ and prolonging survival^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice^[1]
Dosage:

1 nmol
Administration:

i.v.; on days 3 and 10
Result:

Reduced average tumor volume to approximately 1000 mm³ on day 30, whereas control groups exhibited tumor volumes close to 2000 mm³.
Significantly prolonged survival relative to αGalCer.

Related Protocols :

Naïve CD4+ T-cell subset differentiation/polarization

Chemical Information

Molecular Weight 892.30
Formel C₅₂H₉₃NO₁₀
SMILES

OC[C@H]([C@@H]([C@@H]([C@H]1O)O)O)O[C@@H]1OC[C@H](NC(CC2=CC=C(OCC3CCCCCCCCCCCCCCCCCC3)C=C2)=O)[C@H](O)[C@@H](CCCCCCCCCCCCCC)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Sun Q N, et al. All-Hydrocarbon Macrocycle Enables Highly Potent Th1-Biased NKT Cell Agonists for Immunotherapy[J]. JACS Au.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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