JDP2 - Jun dimerization protein 2 Gene

Also Known as JUNDM2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 122953

About JDP2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:75,426,943-75,474,107 (from NCBI)

This gene has 8 transcripts (splice variants), 282 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 5.0), bone marrow (RPKM 4.2) and 25 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

JDP2 Products (4)

mRNA	Protein	Name
NM_001135047.2	NP_001128519.1	jun dimerization protein 2 isoform a
NM_001135048.2	NP_001128520.1	jun dimerization protein 2 isoform a
NM_001135049.1	NP_001128521.1	jun dimerization protein 2 isoform b
NM_130469.3	NP_569736.1	jun dimerization protein 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18671972	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18671972	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of transcription by RNA polymerase II	EXP EXP: Inferred from Experiment	11231009	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18671972	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of RNA polymerase II transcription regulator complex	EXP EXP: Inferred from Experiment	11231009	GOA
located in nucleus	EXP EXP: Inferred from Experiment	11231009	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JDP2 Protein Structure

bZIP_1

0
100
163 a.a.

Protein Preferred Names	Protein Names
jun dimerization protein 2	progesterone receptor co-activator

JDP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	JDP2	Q8WYK2	CREB5	Homo sapiens	Q02930-3	Y2H Array	32296183
Intra	JDP2	Q8WYK2	CREB5	Homo sapiens	Q02930-3	Y2H Prey Pooling	32296183
Intra	JDP2	Q8WYK2	ATF4	Homo sapiens	P18848	Y2H Array	32296183
Intra	JDP2	Q8WYK2	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	32296183
Intra	JDP2	Q8WYK2	IRF2BP1	Homo sapiens	Q8IU81	Pull Down	18671972
Intra	JDP2	Q8WYK2	IRF2BP1	Homo sapiens	Q8IU81	Anti Tag CoIP	18671972
Intra	JDP2	Q8WYK2	IRF2BP1	Homo sapiens	Q8IU81	Anti Bait CoIP	18671972
Intra	JDP2	Q8WYK2	DDIT3	Homo sapiens	P35638	Y2H Array	32296183
Intra	JDP2	Q8WYK2	DDIT3	Homo sapiens	P35638	Y2H Prey Pooling	32296183
Intra	JDP2	Q8WYK2	JUNB	Homo sapiens	P17275	Anti Tag CoIP	18671972

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Granulomatous Amebic Encephalitis	Granulomatous Amoebic Encephalitis Acanthamoeba Encephalitis Acanthamoeba Granulomatous Encephalitis Granulomatous Amebic Encephalitis Due To Acanthamoeba
Primary Amebic Meningoencephalitis	Pam Naegleria Fowleri Infection Meningoencephalitis Caused By Naegleria Fowleri Primary Amoebic Meningoencephalitis
Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy	Autosomal Dominant Adult-Onset Proximal Sma Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type Finkel Disease Smafk Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant Autosomal Dominant Adult Proximal Spinal Muscular Atrophy Finkel Late-Adult Type Sma
Keratitis, Hereditary	Keratitis Autosomal Dominant Keratitis Hereditary Keratitis Dominantly Inherited Keratitis Keratitis Hereditary KERH

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS07034	JDP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19907	Jdp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26408	Jdp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	JDP2	VGNC	VGNC:42185
Felis catus	JDP2	VGNC	VGNC:63004
Bos taurus	JDP2	VGNC	VGNC:30374
Mus musculus	JDP2	MGD	MGI:1932093
Macaca mulatta	JDP2	VGNC	VGNC:73845
Rattus norvegicus	JDP2	RGD	RGD:621611
Others	JDP2	NCBI