Csf2 - colony stimulating factor 2 (granulocyte-macrophage) Gene

Also Known as CSF; Csfgm; GMCSF; Gm-CSf; MGI-IGM

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12981

Summary

Enables cytokine activity. Acts upstream of or within several processes, including embryonic placenta development; myeloid leukocyte differentiation; and positive regulation of cell population proliferation. Located in extracellular space. Is expressed in several structures, including genitourinary system; hemolymphoid system; labyrinthine zone; liver; and lung. Used to study pulmonary alveolar proteinosis. Human ortholog(s) of this gene implicated in acute myeloid leukemia; juvenile myelomonocytic leukemia; neutropenia; pulmonary alveolar proteinosis; and visceral leishmaniasis. Orthologous to human CSF2 (colony stimulating factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Csf2 Products (1)

mRNA	Protein	Name
NM_009969.4	NP_034099.2	granulocyte-macrophage colony-stimulating factor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	1350248	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	1350248	MGI
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	19228596	MGI
acts upstream of or within monocyte differentiation	IDA IDA: Inferred from direct assay	19109256	MGI
acts upstream of or within myeloid dendritic cell differentiation	IDA IDA: Inferred from direct assay	12021780	MGI
acts upstream of or within neutrophil differentiation	IDA IDA: Inferred from direct assay	19109256	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	1350248	MGI
acts upstream of or within regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	10678181	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	9697835	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19228596	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7690439	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
granulocyte-macrophage colony-stimulating factor	colony-stimulating factor granulocyte-macrophage colony stimulating factor 2 put. GM-CSF

Recombinant Csf2 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7069	GM-CSF Protein, Mouse (CHO)	Q14AD9 (A18-K141)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7361	GM-CSF Protein, Mouse	Q14AD9 (A18-K141)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70623	GM-CSF Protein, Mouse (HEK293, His)	P01587 (A18-K141)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73082	GM-CSF Protein, Mouse (HEK293, Fc)	P01587 (A18-K141)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P99207	Lenzilumab		99.64%	Phase 3
HY-P99307	Namilumab	Inhibitor	99.47%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-N7038A	Phytohemagglutinin P	Activator	/	Unkown
HY-RS03231	CSF2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03232	CSF2RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03233	CSF2RB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174733	Human CSF2RA mRNA		/	Unkown
HY-RS16786	Csf2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18089	Csf2ra Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18705	Csf2rb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23226	Csf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24563	Csf2ra Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25192	Csf2rb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990094	Trabikibart		99.17%	Unkown
HY-P990975	Birinkibart		98.26%	Unkown
HY-P990381	Anti-CSF2/GM-CSF Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Csf2	NCBI	NCBI:1437