Dvl3 - dishevelled segment polarity protein 3 Gene

Also Known as b2b2866Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13544

Summary

Enables protein-macromolecule adaptor activity. Involved in canonical Wnt signaling pathway and non-canonical Wnt signaling pathway via JNK cascade. Acts upstream of or within cochlea morphogenesis; outflow tract septum morphogenesis; and planar cell polarity pathway involved in neural tube closure. Located in cytoplasm. Part of Wnt signalosome. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 3. Orthologous to human DVL3 (dishevelled segment polarity protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Dvl3 Products (2)

mRNA Protein Name
NM_001347176.1 NP_001334105.1 segment polarity protein dishevelled homolog DVL-3 isoform 2
NM_007889.3 NP_031915.2 segment polarity protein dishevelled homolog DVL-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
11274398 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
23109420 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IGI
IGI: Inferred from genetic interaction
19008950 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18093802 MGI
acts upstream of or within cochlea morphogenesis IGI
IGI: Inferred from genetic interaction
19008950 MGI
acts upstream of or within heart morphogenesis IGI
IGI: Inferred from genetic interaction
19008950 MGI
involved in non-canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
11274398 MGI
involved in non-canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
23109420 MGI
acts upstream of or within outflow tract septum morphogenesis IMP
IMP: Inferred from mutant phenotype
19008950 MGI
Cellular Component GO Annotation Evidence Verweise Source
part of Wnt signalosome IDA
IDA: Inferred from direct assay
22899650 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17005174 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16501258 MGI
is active in synapse IDA
IDA: Inferred from direct assay
16501258 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

segment polarity protein dishevelled homolog DVL-3

  • dishevelled 3, dsh homolog

Dvl3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Dvl3 Q61062 Vangl1 Mus musculus Q80Z96
Y2H
15456783
Intra
Dvl3 Q61062 Dvl2 Mus musculus Q60838
CoIP
21092292
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04078 DVL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20721 Dvl3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27233 Dvl3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dvl3 NCBI NCBI:1857