Hhat - hedgehog acyltransferase Gene

Also Known as Skn; AP-2CRE; 2810432O22Rik; Tg(TFAP2A-cre)1Will

Species: Mus musculus

Gene Type: protein coding
Gene ID: 226861

Summary

Enables palmitoyltransferase activity. Involved in N-terminal peptidyl-L-cysteine N-palmitoylation. Acts upstream of or within protein palmitoylation and smoothened signaling pathway. Predicted to be located in Golgi apparatus. Predicted to be active in endoplasmic reticulum. Is expressed in branchial arch; embryo; embryo ectoderm; and limb. Used to study chondrodysplasia-pseudohermaphroditism syndrome. Human ortholog(s) of this gene implicated in chondrodysplasia-pseudohermaphroditism syndrome. Orthologous to human HHAT (hedgehog Acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Hhat Products (1)

mRNA Protein Name
NM_144881.5 NP_659130.2 protein-cysteine N-palmitoyltransferase HHAT precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables palmitoyltransferase activity IMP
IMP: Inferred from mutant phenotype
15075292 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in N-terminal peptidyl-L-cysteine N-palmitoylation IMP
IMP: Inferred from mutant phenotype
15075292 MGI
acts upstream of or within protein palmitoylation IMP
IMP: Inferred from mutant phenotype
15075292 MGI
acts upstream of or within smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
15075292 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-cysteine N-palmitoyltransferase HHAT

  • skinny hedgehog protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-18366A RU-SKI 43 hydrochloride Inhibitor 98.81% Unkown
HY-18366 RU-SKI 43 Inhibitor / Unkown
HY-123781A RUSKI-201 dihydrochloride Inhibitor 98.20% Unkown
HY-161175 IMP-1575 Inhibitor / Unkown
HY-RS06157 HHAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123781 RUSKI-201 Inhibitor / Unkown
HY-RS20752 Hhat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27264 Hhat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hhat NCBI NCBI:55733