DICER1 - dicer 1, ribonuclease III Gene

Also Known as DCR1; GLOW; MNG1; aviD; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23405

About DICER1

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:95,086,228-95,158,010 (from NCBI)

This gene has 33 transcripts (splice variants), 205 orthologues and is associated with 143 phenotypes. Ubiquitous expression in appendix (RPKM 6.6), placenta (RPKM 6.6) and 25 other tissues.

Summary

This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong Antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]

DICER1 Products (28)

mRNA	Protein	Name
NM_001195573.1	NP_001182502.1	endoribonuclease Dicer isoform 2
NM_001271282.3	NP_001258211.1	endoribonuclease Dicer isoform 1
NM_001291628.2	NP_001278557.1	endoribonuclease Dicer isoform 1
NM_001395677.1	NP_001382606.1	endoribonuclease Dicer isoform 1
NM_001395678.1	NP_001382607.1	endoribonuclease Dicer isoform 1
NM_001395679.1	NP_001382608.1	endoribonuclease Dicer isoform 1
NM_001395680.1	NP_001382609.1	endoribonuclease Dicer isoform 1
NM_001395682.1	NP_001382611.1	endoribonuclease Dicer isoform 1
NM_001395683.1	NP_001382612.1	endoribonuclease Dicer isoform 1
NM_001395684.1	NP_001382613.1	endoribonuclease Dicer isoform 1
NM_001395685.1	NP_001382614.1	endoribonuclease Dicer isoform 3
NM_001395686.1	NP_001382615.1	endoribonuclease Dicer isoform 4
NM_001395687.1	NP_001382616.1	endoribonuclease Dicer isoform 5
NM_001395688.1	NP_001382617.1	endoribonuclease Dicer isoform 5
NM_001395689.1	NP_001382618.1	endoribonuclease Dicer isoform 5
NM_001395690.1	NP_001382619.1	endoribonuclease Dicer isoform 5
NM_001395691.1	NP_001382620.1	endoribonuclease Dicer isoform 6
NM_001395692.1	NP_001382621.1	endoribonuclease Dicer isoform 7
NM_001395693.1	NP_001382622.1	endoribonuclease Dicer isoform 7
NM_001395694.1	NP_001382623.1	endoribonuclease Dicer isoform 7
NM_001395695.1	NP_001382624.1	endoribonuclease Dicer isoform 7
NM_001395696.1	NP_001382625.1	endoribonuclease Dicer isoform 8
NM_001395697.1	NP_001382626.1	endoribonuclease Dicer isoform 9
NM_001395698.1	NP_001382627.1	endoribonuclease Dicer isoform 10
NM_001395699.1	NP_001382628.1	endoribonuclease Dicer isoform 11
NM_001395700.1	NP_001382629.1	endoribonuclease Dicer isoform 12
NM_030621.4	NP_085124.2	endoribonuclease Dicer isoform 1
NM_177438.3	NP_803187.1	endoribonuclease Dicer isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	25549615	GOA
enables RNA endonuclease activity	IMP IMP: Inferred from mutant phenotype	18325616	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	12411504	GOA
enables double-stranded RNA binding	IMP IMP: Inferred from mutant phenotype	19701182	GOA
contributes to pre-miRNA binding	IDA IDA: Inferred from direct assay	18178619	GOA
enables pre-miRNA binding	IDA IDA: Inferred from direct assay	18508075	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12526743	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	12526743	GOA
enables ribonuclease III activity	EXP EXP: Inferred from Experiment	12411504	GOA
enables ribonuclease III activity	IDA IDA: Inferred from direct assay	21753850	GOA
enables siRNA binding	IDA IDA: Inferred from direct assay	15973356	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in RISC complex assembly	IDA IDA: Inferred from direct assay	15973356	GOA
involved in global gene silencing by mRNA cleavage	IMP IMP: Inferred from mutant phenotype	15973356	GOA
involved in miRNA processing	IDA IDA: Inferred from direct assay	15973356	GOA
involved in miRNA processing	IMP IMP: Inferred from mutant phenotype	23322395	GOA
acts upstream of negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22105995	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23322395	GOA
acts upstream of negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	26435691	GOA
acts upstream of negative regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	26435691	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	15973356	GOA
involved in siRNA processing	IDA IDA: Inferred from direct assay	15973356	GOA
involved in siRNA processing	IMP IMP: Inferred from mutant phenotype	19701182	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
NOT part of RISC complex	IDA IDA: Inferred from direct assay	16357216	GOA
part of RISC complex	IDA IDA: Inferred from direct assay	17531811	GOA
part of RISC-loading complex	IDA IDA: Inferred from direct assay	15973356	GOA
part of RISC-loading complex	IPI IPI: Inferred from physical interaction	23661684	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	28159509	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19022417	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DICER1 Protein Structure

DEAD

Helicase_C

Dicer_dimer

PAZ

Ribonuclease_3

0
300
600
900
1200
1500
1800
1922 a.a.

Protein Preferred Names	Protein Names
endoribonuclease Dicer	Dicer1, Dcr-1 homolog

DICER1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Cross	DICER1	Q9UPY3	M	Nipah virus	Q9IK90	Anti Bait CoIP	28904190
Intra	DICER1	Q9UPY3	PIWIL1	Homo sapiens	Q96J94	Pull Down	14749716
Intra	DICER1	Q9UPY3	PIWIL1	Homo sapiens	Q96J94	CoIP	14749716
Intra	DICER1	Q9UPY3	AGO2	Homo sapiens	Q9UKV8	Anti Bait CoIP	25446899
Intra	DICER1	Q9UPY3	AGO2	Homo sapiens	Q9UKV8	Ribonuclease Assay	23661684
Intra	DICER1	Q9UPY3	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	21858095
Intra	DICER1	Q9UPY3	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	23622242
Intra	DICER1	Q9UPY3	AGO2	Homo sapiens	Q9UKV8	Pull Down	14749716
Intra	DICER1	Q9UPY3	AGO2	Homo sapiens	Q9UKV8	Y2H	14749716
Intra	DICER1	Q9UPY3	AGO2	Homo sapiens	Q9UKV8	CoIP	14749716
Cross	DICER1	Q9UPY3	Ago2	Mus musculus	Q8CJG0	Anti Bait CoIP	12526743
Intra	DICER1	Q9UPY3	EIF2AK2	Homo sapiens	P19525	Anti Tag CoIP	21903422
Intra	DICER1	Q9UPY3	ADAR	Homo sapiens	P55265-1	Cleavage	23622242
Intra	DICER1	Q9UPY3	ADAR	Homo sapiens	P55265-1	Anti Tag CoIP	23622242
Intra	DICER1	Q9UPY3	ADAR	Homo sapiens	P55265-5	Anti Tag CoIP	23622242
Intra	DICER1	Q9UPY3	ADAR	Homo sapiens	P55265-5	Cleavage	23622242
Intra	DICER1	Q9UPY3	TNFSF12	Homo sapiens	O43508	Anti Tag CoIP	29657270
Intra	DICER1	Q9UPY3	TNFSF12	Homo sapiens	O43508	Y2H	29657270
Intra	DICER1	Q9UPY3	PRKRA	Homo sapiens	O75569	Anti Bait CoIP	21858095
Intra	DICER1	Q9UPY3	PRKRA	Homo sapiens	O75569	Ribonuclease Assay	23661684
Intra	DICER1	Q9UPY3	PRKRA	Homo sapiens	O75569	GMS	23661684
Intra	DICER1	Q9UPY3	PRKRA	Homo sapiens	O75569	Anti Tag CoIP	16424907
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Y2H	16142218
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Ribonuclease Assay	23661684
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Cosedimentation	16142218
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	16142218
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	23622242
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Anti Bait CoIP	33328224
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Anti Bait CoIP	16142218
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Anti Bait CoIP	25446899
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Affinity Chrom	19804757
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	16424907
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Anti Bait CoIP	21858095
Intra	DICER1	Q9UPY3	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	21858095
Cross	DICER1	Q9UPY3	rex_htl1a	Human T-cell leukemia virus 1	P0C205	IF	20869963

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Global Developmental Delay, Lung Cysts, Overgrowth, And Wilms Tumor	Glow Syndrome GLOW Glow Syndrome, Somatic Mosaic Global Developmental Delay - Lung Cysts - Overgrowth - Wilms Tumor Syndrome Global Developmental Delay-Lung Cysts-Overgrowth-Wilms Tumor Syndrome
Goiter, Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors	Euthyroid Goiter MNG1 Simple Goiter Goiter Euthyroid Goiter, Nontoxic, With Intrathyroidal Calcification Multinodular Goiter, Adolescent Familial Multinodular Goiter Fmng Familial Mng Familial Multinodular Goiter Syndrome Goiter Multinodular 1, With Or Without Sertoli-Leydig Cell Tumors Goiter Nontoxic With Intrathyroidal Calcification Goiter Non-Toxic With Intrathyroidal Calcification Multinodular Goiter Adolescent Goiter, Multinodular, Type 1, With/Without Sertoli-Leydig Cell Tumors Endemic Goiter
Pleuropulmonary Blastoma	PPB Ppb Familial Tumor And Dysplasia Syndrome Ppbftds Pulmonary Blastoma Blastoma, Pleuropulmonary Dicer1 Syndrome Respiratory Tract Neoplasms
Rhabdomyosarcoma, Embryonal, 2	RMSE2 Rhabdomyosarcoma, Embryonal, Type 2
Dicer1 Syndrome	Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome Ppb Familial Tumor Susceptibility Syndrome Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Dicer1-Related Pleuropulmonary Blastoma Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome Ppbftds Doid:0081063
Pineoblastoma	Pineal Pnet Pinealoma Pineal Gland Neoplasm Pineocytoma Tumor Of The Pineal Region
Embryonal Rhabdomyosarcoma	Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma Embryonal Botryoid Rhabdomyosarcoma Erms Spindle Cell Rhabdomyosarcomas
Rhabdomyosarcoma
Bap1 Tumor Predisposition Syndrome	Bap1-Related Tumor Predisposition Syndrome Common Syndrome Bap1 Cancer Syndrome Bap1-Tpds Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms Tumor Predisposition Syndrome Tumor Susceptibility Linked To Germline Bap1 Mutations Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms Tumor Predisposition
Inherited Cancer-Predisposing Syndrome	Hereditary Cancer-Predisposing Syndrome
Blastoma	Embryoma
Supratentorial Primitive Neuroectodermal Tumor	Supratentorial Pnet Supratentorial Embryonal Tumor, Not Otherwise Specified Ewings Sarcoma-Primitive Neuroectodermal Tumor
Pulmonary Blastoma	Blastoma Of Lung Pneumoblastoma
Gynandroblastoma	Ovarian Gynandroblastoma
Malignant Sertoli-Leydig Cell Tumor Of The Ovary	Virilizing Ovarian Tumor Androblastoma Arrhenoblastoma Ovarian Sertoli-Leydig Cell Cancer Ovarian Malignant Sertoli-Leydig Cell Tumor Sertoli-Leydig Cell Tumor Of Ovary Sertoli-Leydig Cell Tumor
Nephroma	Benign Nephroma
Maligant Granulosa Cell Tumor Of The Ovary	Granulosa Cell Cancer Granulosa Cell Malignant Tumor Maligant Granulosa Cell Tumor Of Ovary
Goiter	Goitre
Pulmonary Sequestration
Pineal Gland Cancer	Tumor Of The Pineal Region Malignant Pineal Region Tumor Malignant Tumor Of Pineal Gland Neoplasm Of Pineal Gland Neoplasm Of The Pineal Region Pineal Body Neoplasm Pineocytic Tumor Malignant Neoplasm Of Pineal Gland Pineal Gland Neoplasm Pineocytoma
Sertoli-Leydig Cell Tumor	Sertoli-Leydig Cell Tumors Androblastoma Of Ovary Arrhenoblastoma Arrhenoblastoma Of Ovary Sertoli-Leydig Cell Tumor Of The Ovary Sertoli-Leydig Cell Tumor Of Intermediate Differentiation Sertoli-Leydig Cell Tumor Of Ovary
Adenosarcoma	Mullerian Adenosarcoma
Central Nervous System Sarcoma	Sarcoma Of The Cns
Kidney Cortex Disease
Spinal Cord Sarcoma	Sarcoma Of The Spinal Cord
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Medulloepithelioma	Diktyoma, Malignant Medulloepithelioma, Central Nervous System Medulloepithelioma Of The Central Nervous System
Botryoid Rhabdomyosarcoma	Sarcoma Botryoides Botryoid Sarcoma Botryoid-Type Embryonal Rhabdomyosarcoma
Central Nervous System Primitive Neuroectodermal Neoplasm	Cpnet
Ovarian Sex-Cord Stromal Tumor	Ovarian Sex Cord Tumor With Annular Tubules Ovarian Sex Cord-Stromal Tumor Stromal Tumor Of Ovary
Adult Cystic Nephroma	Multilocular Cystic Nephroma, Mixed Epithelial Stromal Tumour And Renal Epithelial Stromal Tumour
Juvenile Type Testicular Granulosa Cell Tumor	Juvenile Granulosa Cell Tumor Juvenile Granulosa Cell Tumour Juvenile Type Granulosa Cell Neoplasm Juvenile Type Granulosa Cell Tumor Juvenile Type Granulosa Cell Tumour Juvenile Type Testicular Granulosa Cell Tumour
Testicular Granulosa Cell Tumor	Granulosa Cell Tumor Of Testis Granulosa Cell Tumour Of Testis Testicular Granulosa Cell Tumour
Frontal Sinus Cancer	Malignant Neoplasm Of Frontal Sinus Malignant Tumor Of Frontal Sinus Malignant Tumor Of The Frontal Sinus Neoplasm Of Frontal Sinus
Frontal Sinus Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Frontal Sinus
Pineal Parenchymal Tumor Of Intermediate Differentiation	Pineal Parenchymal Tumour Of Intermediate Differentiation Pineal Parenchymal Tumors Of Intermediate Differentiation Pptid
Kidney Benign Neoplasm	Renal And Ureteral Tumor Benign Kidney Neoplasm
Kidney Sarcoma	Renal Sarcoma Sarcoma Of Kidney
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Malignant Cystic Nephroma	Malignant Multilocular Cystic Nephroma Cystic Partially Differentiated Nephroblastoma
Sex Cord-Gonadal Stromal Tumor	Sex Cord-Gonadal Stromal Tumour Sex Cord Stromal Tumour Sex Cord-Stromal Neoplasm Specialized Gonadal Neoplasm Specialized Gonadal Tumor Specialized Gonadal Tumour Sex Cord-Gonadal Stromal Tumors Sex Cord-Stromal Tumor Malignant Testicular Sex Cord-Stromal Tumor Sex Cord Stromal Tumor Of Testis
Multinodular Goiter
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia
Pleural Disease	Pleural Diseases Disorder Of Pleura Non-Neoplastic Pleural Disease Pleural Disorders Non-Neoplastic Pleural Disorder
Perlman Syndrome	Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor PRLMNS Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome Renal Hamartomas Nephroblastomatosis And Fetal Gigantism Nephroblastoma Fetal Macrosomia
Ciliary Dyskinesia, Primary, 43	CILD43 Primary Ciliary Dyskinesia 43 Ciliary Dyskinesia, Primary, 43, With Or Without Situs Inversus Primary Ciliary Dyskinesia 43 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 43 With Or Without Situs Inversus
Pineal Region Choriocarcinoma	Pineal Choriocarcinoma
Cerebrum Cancer	Cerebral Cancer Neoplasm Of Cerebrum Tumor Of Cerebrum Malignant Neoplasm Of Cerebrum
Supratentorial Cancer	Supratentorial Neoplasms Brain Neoplasm, Supratentorial Malignant Supratentorial Tumor Cancer, Supratentorial
Spontaneous Tension Pneumothorax	Tension Pneumothorax
Macular Degeneration, Age-Related, 1	Macular Degeneration Age-Related Macular Degeneration Macular Degeneration, Age-Related Age Related Macular Degeneration Age Related Macular Degeneration 1 ARMD1 Senile Macular Degeneration Maculopathy, Age-Related, 1 Macular Degeneration, Age-Related, Reduced Risk Of Age Related Maculopathy 1 Age Related Maculopathies Age Related Maculopathy Senile Macular Retinal Degeneration Macular Degeneration Of Retina Age-Related Maculopathy Amd Armd Age-Related Maculopathy, Susceptibility To Maculopathy Age-Related Macular Degeneration, Age-Related, 1, Susceptibility To Maculopathy, Age-Related Macular Degeneration, Age-Related, Type 1 Macular Degeneration, Age-Related, 2
Skeletal Muscle Cancer	Malignant Tumor Of Skeletal Muscle Skeletal Muscle Neoplasm
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Chromosomal Deletion Syndrome
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Atrial Septal Defect 8	ASD8 Atrial Heart Septal Defect 8 Septal Defect, Atrial, Type 8
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03766	DICER1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DICER1	VGNC	VGNC:28063
Mus musculus	DICER1	MGD	MGI:2177178
Macaca mulatta	DICER1	VGNC	VGNC:71638
Canis familiaris	DICER1	VGNC	VGNC:39958
Felis catus	DICER1	VGNC	VGNC:61490
Rattus norvegicus	DICER1	RGD	RGD:1309381
Others	DICER1	NCBI