ZDHHC1 - zinc finger DHHC-type containing 1 Gene

Also Known as DHHC-1; ZNF377; C16orf1; HSU90653

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29800

About ZDHHC1

This gene has 6 transcripts (splice variants), 215 orthologues and 17 paralogues. Ubiquitous expression in ovary (RPKM 6.2), testis (RPKM 6.1) and 24 other tissues.

Summary

Enables palmitoyltransferase activity. Involved in Antiviral innate immune response; positive regulation of defense response to virus by host; and protein palmitoylation. Located in Golgi apparatus and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC1 Products (2)

mRNA Protein Name
NM_001323627.2 NP_001310556.1 palmitoyltransferase ZDHHC1 isoform 2
NM_013304.3 NP_037436.1 palmitoyltransferase ZDHHC1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables palmitoyltransferase activity IDA
IDA: Inferred from direct assay
23034182 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25299331 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in antiviral innate immune response IMP
IMP: Inferred from mutant phenotype
25299331 GOA
involved in positive regulation of defense response to virus by host IMP
IMP: Inferred from mutant phenotype
25299331 GOA
involved in protein palmitoylation IDA
IDA: Inferred from direct assay
23034182 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
25299331 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16647879 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
25299331 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC1 Protein Structure

DHHC

DHHC: DHHC palmitoyltransferase (112 - 283)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

palmitoyltransferase ZDHHC1

  • DHHC domain-containing cysteine-rich protein 1

ZDHHC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ZDHHC1 Q8WTX9 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRT83 Homo sapiens P78385
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRT83 Homo sapiens P78385
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 GOPC Homo sapiens Q9HD26-2
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 GOPC Homo sapiens Q9HD26-2
Validated Y2H
32296183
Intra
ZDHHC1 Q8WTX9 GOPC Homo sapiens Q9HD26-2
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
ZDHHC1 Q8WTX9 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
ZDHHC1 Q8WTX9 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
ZDHHC1 Q8WTX9 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
ZDHHC1 Q8WTX9 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 10

  • Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2

  • Combined Immunodeficiency Due To Stim1 Deficiency

  • IMD10

  • Stim1 Deficiency

  • Cid Due To Stim1 Deficiency

  • Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2

  • Immunodeficiency, Type 10
T Cell And Nk Cell Immunodeficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS16011 ZDHHC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZDHHC1 MGD MGI:1918046
Canis familiaris ZDHHC1 VGNC VGNC:48577
Macaca mulatta ZDHHC1 VGNC VGNC:79102
Bos taurus ZDHHC1 VGNC VGNC:37126
Rattus norvegicus ZDHHC1 RGD RGD:1589775
Felis catus ZDHHC1 VGNC VGNC:67200
Others ZDHHC1 NCBI