DNTTIP2 - deoxynucleotidyltransferase terminal interacting protein 2 Gene

Also Known as ERBP; FCF2; TdIF2; HSU15552; LPTS-RP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 30836

About DNTTIP2

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,866,284-93,879,206 (from NCBI)

This gene has 7 transcripts (splice variants) and 217 orthologues. Ubiquitous expression in bone marrow (RPKM 37.4), testis (RPKM 17.8) and 25 other tissues.

Summary

This gene is thought to be involved in chromatin remodeling and gene transcription. The encoded nuclear protein binds to and enhances the transcriptional activity of the Estrogen receptor alpha, and also interacts with terminal deoxynucleotidyltransferase. The expression profile of this gene is a potential biomarker for chronic obstructive pulmonary disease. [provided by RefSeq, Dec 2010]

DNTTIP2 Products (1)

mRNA Protein Name
NM_014597.5 NP_055412.2 deoxynucleotidyltransferase terminal-interacting protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNTTIP2 Protein Structure

Fcf2

Fcf2: Fcf2 pre-rRNA processing (635 - 731)

  • 0
  • 200
  • 400
  • 600
  • 756 a.a.
Protein Preferred Names Protein Names

deoxynucleotidyltransferase terminal-interacting protein 2

  • LPTS-interacting protein 2

DNTTIP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DNTTIP2 Q5QJE6 CAVIN1 Homo sapiens Q6NZI2
Validated Y2H
32296183
Intra
DNTTIP2 Q5QJE6 CAVIN1 Homo sapiens Q6NZI2
Y2H Array
32296183
Intra
DNTTIP2 Q5QJE6 CAVIN1 Homo sapiens Q6NZI2
Y2H Prey Pooling
32296183
Intra
DNTTIP2 Q5QJE6 RNF8 Homo sapiens O76064
Y2H Prey Pooling
32296183
Intra
DNTTIP2 Q5QJE6 RNF8 Homo sapiens O76064
Y2H Array
32296183
Intra
DNTTIP2 Q5QJE6 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
DNTTIP2 Q5QJE6 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
DNTTIP2 Q5QJE6 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
DNTTIP2 Q5QJE6 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
DNTTIP2 Q5QJE6 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
DNTTIP2 Q5QJE6 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03918 DNTTIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22001 Dnttip2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28518 Dnttip2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DNTTIP2 MGD MGI:1923173
Canis familiaris DNTTIP2 VGNC VGNC:40041
Rattus norvegicus DNTTIP2 RGD RGD:6497192
Bos taurus DNTTIP2 VGNC VGNC:28152
Felis catus DNTTIP2 VGNC VGNC:61567
Macaca mulatta DNTTIP2 VGNC VGNC:99896
Others DNTTIP2 NCBI