EIF3L - eukaryotic translation initiation factor 3 subunit L Gene

Also Known as EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51386

About EIF3L

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:37,849,419-37,889,407 (from NCBI)

This gene has 15 transcripts (splice variants) and 225 orthologues. Ubiquitous expression in ovary (RPKM 248.8), thyroid (RPKM 164.0) and 25 other tissues.

Summary

Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3L Products (3)

mRNA	Protein	Name
NM_001242923.2	NP_001229852.1	eukaryotic translation initiation factor 3 subunit L isoform 2
NM_001363785.2	NP_001350714.1	eukaryotic translation initiation factor 3 subunit L isoform 3
NM_016091.4	NP_057175.1	eukaryotic translation initiation factor 3 subunit L isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA
involved in viral translational termination-reinitiation	IDA IDA: Inferred from direct assay	21347434	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3L Protein Structure

Paf67

0
100
200
300
400
500
564 a.a.

Protein Preferred Names	Protein Names
eukaryotic translation initiation factor 3 subunit L	eIEF associated protein HSPC021

EIF3L Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	EIF3L	Q9Y262	EIF3E	Homo sapiens	P60228	Pull Down	23623729
Intra	EIF3L	Q9Y262	EIF3E	Homo sapiens	P60228	Anti Tag CoIP	18599441
Intra	EIF3L	Q9Y262	EIF3E	Homo sapiens	P60228	Anti Tag CoIP	33961781
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	28514442
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	18599441
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Y2H Array	32296183
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	SLCA	19748344
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Pull Down	23623729
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Y2H Prey Pooling	25416956
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Anti Tag CoIP	33961781
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Validated Y2H	25416956
Intra	EIF3L	Q9Y262	EIF3K	Homo sapiens	Q9UBQ5	Y2H Prey Pooling	32296183
Intra	EIF3L	Q9Y262	EIF3B	Homo sapiens	P55884	Anti Tag CoIP	33961781
Cross	EIF3L	Q9Y262	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Yellow Fever	Urban Yellow Fever Jungle Yellow Fever Sylvatic Yellow Fever Yf Yellow Fever, Sylvan Bronze John Yellow Jack Yf- [Yellow Fever] Febris Flava
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma	DMSMFH Bone Dysplasia With Medullary Fibrosarcoma Bdmf Bone Dysplasia With Malignant Fibrous Histiocytoma Hardcastle Syndrome Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome Myopathy, Limb-Girdle, With Bone Fragility Bone Dysplasia-Medullary Fibrosarcoma Syndrome Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome Dms-Mfh Limb-Girdle Myopathy With Bone Fragility Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS04268	EIF3L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21563	Eif3l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28081	Eif3l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	EIF3L	VGNC	VGNC:61786
Mus musculus	EIF3L	MGD	MGI:2386251
Rattus norvegicus	EIF3L	RGD	RGD:1308230
Bos taurus	EIF3L	VGNC	VGNC:28402
Canis familiaris	EIF3L	VGNC	VGNC:40278
Macaca mulatta	EIF3L	VGNC	VGNC:84764
Others	EIF3L	NCBI