ATF7IP - activating transcription factor 7 interacting protein Gene

Also Known as AM; MCAF; p621; MCAF1; ATF-IP; ATF7IP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55729

About ATF7IP

Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:14,365,682-14,502,930 (from NCBI)

This gene has 24 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 8.4), testis (RPKM 8.3) and 25 other tissues.

Summary

ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010]

ATF7IP Products (10)

mRNA	Protein	Name
NM_001286514.2	NP_001273443.1	activating transcription factor 7-interacting protein 1 isoform 3
NM_001286515.2	NP_001273444.1	activating transcription factor 7-interacting protein 1 isoform 4
NM_001388179.1	NP_001375108.1	activating transcription factor 7-interacting protein 1 isoform 5
NM_001388180.1	NP_001375109.1	activating transcription factor 7-interacting protein 1 isoform 2
NM_001388181.1	NP_001375110.1	activating transcription factor 7-interacting protein 1 isoform 2
NM_001388182.1	NP_001375111.1	activating transcription factor 7-interacting protein 1 isoform 2
NM_001388183.1	NP_001375112.1	activating transcription factor 7-interacting protein 1 isoform 2
NM_001388184.1	NP_001375113.1	activating transcription factor 7-interacting protein 1 isoform 3
NM_018179.5	NP_060649.3	activating transcription factor 7-interacting protein 1 isoform 2
NM_181352.2	NP_851997.1	activating transcription factor 7-interacting protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12665582	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	12665582	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12665582	GOA
involved in positive regulation of DNA methylation-dependent heterochromatin formation	IMP IMP: Inferred from mutant phenotype	27732843	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12665582	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	27732843	GOA
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	27732843	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	12665582	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	27732843	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
activating transcription factor 7-interacting protein 1	ATF-interacting protein

ATF7IP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	ATF7IP	Q6VMQ6	ARL14EP	Homo sapiens	Q8N8R7	Anti Tag CoIP	33961781
Intra	ATF7IP	Q6VMQ6	GTF2IRD1	Homo sapiens	Q9UHL9	Y2H	26275350
Intra	ATF7IP	Q6VMQ6	DISC1	Homo sapiens	Q9NRI5	Y2H	12812986

Cross: Cross-species interaction Intra: Intraspecies interaction

ATF7IP Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P810124	ATF-7IP Antibody (YA9468)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Liver Carcinoma In Situ	Carcinoma In Situ Of Liver And Biliary System Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts
Optic Atrophy 11	OPA11 Atrophy, Optic, Type 11
Uterine Corpus Endometrial Carcinoma
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor
Alpha Thalassemia-Intellectual Disability Syndrome Type 1	Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16 Atr Syndrome Linked To Chromosome 16 Atr Syndrome, Deletion Type Atr-16 Syndrome Alpha Thalassemia-Retardation Syndrome Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type Alpha-Thalassemia/Mental Retardation Syndrome, Type 1 Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01137	ATF7IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20138	Atf7ip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26641	Atf7ip Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATF7IP	MGD	MGI:1858965
Felis catus	ATF7IP	VGNC	VGNC:59994
Macaca mulatta	ATF7IP	VGNC	VGNC:70100
Bos taurus	ATF7IP	VGNC	VGNC:26246
Canis familiaris	ATF7IP	VGNC	VGNC:38213
Rattus norvegicus	ATF7IP	RGD	RGD:1306030
Others	ATF7IP	NCBI