SLC7A10 - solute carrier family 7 member 10 Gene

Also Known as ASC1; asc-1; HASC-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56301

About SLC7A10

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:33,208,664-33,225,850 (from NCBI)

This gene has 5 transcripts (splice variants), 301 orthologues and 12 paralogues. Broad expression in fat (RPKM 24.7), ovary (RPKM 10.1) and 14 other tissues.

Summary

SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several Other neutral Amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008]

SLC7A10 Products (1)

mRNA Protein Name
NM_019849.3 NP_062823.1 asc-type amino acid transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables neutral L-amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
10863037 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in neutral amino acid transport IDA
IDA: Inferred from direct assay
10863037 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC7A10 Protein Structure

AA_permease_2

AA_permease_2: Amino acid permease (40 - 443)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 523 a.a.
Protein Preferred Names Protein Names

asc-type amino acid transporter 1

  • solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10

SLC7A10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SLC7A10 Q9NS82 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
SLC7A10 Q9NS82 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cystinuria

  • CSNU

  • Cystinuria Type B

  • Cystinuria Type A

  • Cystinuria, Type I, Formerly

  • Csnu1, Formerly

  • Cystinuria, Type Ii, Formerly

  • Cystinuria, Type Iii, Formerly

  • Csnu3, Formerly

  • Cystinuria, Type Non-I, Formerly

  • Cystinuria-Lysinuria

  • Cystinuria-Lysinuria Syndrome

  • Csnu1

  • Csnu3

  • Cystinuria 1

  • Cystinuria Type A/B

  • Cystinuria Type I

  • Cystinuria Type Ii

  • Cystinuria Type Iii

  • Cystinuria Type Non-I

  • Cystinuria, Type A/B

  • Cystinuria Type 1

  • Cystinuria - Lysinuria

  • Csnu - [Cystinuria]

  • Cystine Disease
Hyperekplexia

  • Hereditary Hyperekplexia

  • Kok Disease

  • Congenital Stiff Man Syndrome

  • Familial Startle Disease

  • Sthe

  • Stiff-Baby Syndrome

  • Hereditary Hyperexplexia

  • Startle Disease

  • Exaggerated Startle Reaction

  • Hyperexplexia Hereditary

  • Startle Disease, Familial

  • Startle Reaction, Exaggerated

  • Stiff-Man Syndrome, Congenital

  • Stiff-Person Syndrome, Congenital

  • Congenital Stiff-Man Syndrome

  • Congenital Stiff-Person Syndrome

  • Familial Hyperekplexia

  • Startle Syndrome

  • Stiff Baby Syndrome

  • Hyperekplexia, Hereditary

  • Stiff-Person Syndrome
Hypotonia-Cystinuria Syndrome

  • Cystinuria With Mitochondrial Disease

  • 2p21 Microdeletion Syndrome

  • HCS

  • Homozygous 2p16 Deletion Syndrome, Formerly

  • 2p21 Deletion Syndrome

  • Del(2)(P21)

  • Monosomy 2p21

  • Atypical Hypotonia-Cystinuria Syndrome

  • Atypical Hcs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-120170 BMS-466442 Inhibitor 98.24% Unkown
HY-RS13324 SLC7A10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19553 Slc7a10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26049 Slc7a10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC7A10 MGD MGI:1858261
Canis familiaris SLC7A10 VGNC VGNC:46471
Bos taurus SLC7A10 VGNC VGNC:34925
Felis catus SLC7A10 VGNC VGNC:65422
Rattus norvegicus SLC7A10 RGD RGD:621672
Macaca mulatta SLC7A10 VGNC VGNC:77627
Others SLC7A10 NCBI