RBL1 - RB transcriptional corepressor like 1 Gene

Also Known as PRB1; p107; CP107

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5933

About RBL1

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,996,349-37,095,997 (from NCBI)

This gene has 4 transcripts (splice variants), 194 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 3.5), bone marrow (RPKM 2.8) and 25 other tissues.

Summary

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RBL1 Products (4)

mRNA Protein Name
NM_001323281.2 NP_001310210.1 retinoblastoma-like protein 1 isoform c
NM_001323282.2 NP_001310211.1 retinoblastoma-like protein 1 isoform c
NM_002895.5 NP_002886.2 retinoblastoma-like protein 1 isoform a
NM_183404.4 NP_899662.1 retinoblastoma-like protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
25100735 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
1331501 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in negative regulation of cellular senescence IMP
IMP: Inferred from mutant phenotype
28595801 GOA
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
25100735 GOA
involved in regulation of lipid kinase activity IDA
IDA: Inferred from direct assay
16286473 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in nucleoplasm IDA
IDA: Inferred from direct assay
8245034 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBL1 Protein Structure

DUF3452

DUF3452: Domain of unknown function (DUF3452) (75 - 212)

RB_A

RB_A: Retinoblastoma-associated protein A domain (385 - 578)

RB_B

RB_B: Retinoblastoma-associated protein B domain (786 - 944)

Rb_C

Rb_C: Rb C-terminal domain (958 - 1046)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1068 a.a.
Protein Preferred Names Protein Names

retinoblastoma-like protein 1

  • 107 kDa retinoblastoma-associated protein

RBL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
RBL1 P28749 DYRK1A Homo sapiens Q13627
BiFC
23602568
Intra
RBL1 P28749 FOXO3 Homo sapiens O43524
Pull Down
25609649
Intra
RBL1 P28749 CDK4 Homo sapiens P11802
Protein Kinase Assay
22094256
Intra
RBL1 P28749 PPP2CA Homo sapiens P67775
CoIP
15467457
Intra
RBL1 P28749 PPP2CA Homo sapiens P67775
Phosphatase Assay
15467457
Intra
RBL1 P28749 DGKZ Homo sapiens Q13574-2
Pull Down
16286473
Intra
RBL1 P28749 BEGAIN Homo sapiens Q9BUH8
Y2H Pooling
16189514
Cross
RBL1 P28749 E7 Human papillomavirus P03129
Affinity Chrom
16061792
Cross
RBL1 P28749 E7 Human papillomavirus P03129
SLC
22898364
Cross
RBL1 P28749 e1a_ade05 Human adenovirus C P03255
Competition Binding
1331501
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Bilateral Retinoblastoma
Retinal Cancer

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms

  • Malignant Retinal Neoplasm

  • Malignant Tumor Of Retina

  • Neoplasm Of Retina

  • Retinal Tumor

  • Retinal Neoplasm

  • Cancer Of The Retina

  • Malignant Retinal Tumour

  • Malignant Tumour Of Retina

  • Primary Malignant Neoplasm Of Retina
Cecal Benign Neoplasm

  • Cecal Neoplasms

  • Cecum Neoplasm

  • Neoplasm Of Caecum

  • Cecal Neoplasm

  • Cecum Carcinoma

  • Malignant Neoplasm Of Cecum
Cecum Adenoma

  • Caecum Adenoma
Papilloma

  • Papillomatosis
Familial Retinoblastoma

  • Hereditary Retinoblastoma

  • Retinoblastoma
Unilateral Retinoblastoma
Ocular Cancer

  • Eye Neoplasm

  • Eye Carcinoma

  • Eye Cancer

  • Eye Neoplasms

  • Malignant Eye Neoplasm

  • Neoplasm Of Eye

  • Neoplasm Of Eye Proper

  • Ocular Tumor

  • Carcinoma Of Eye

  • Ocular Carcinoma

  • Malignant Tumor Of Eye
Intraocular Retinoblastoma

  • Pediatric Intraocular Retinoblastoma
Focal Epithelial Hyperplasia

  • Heck'S Disease

  • Heck Disease

  • Multifocal Epithelial Hyperplasia
Retinal Disease

  • Retinal Diseases

  • Retinal Disorder

  • Retinal Disorders
Osteogenic Sarcoma

  • Osteosarcoma

  • OSRC

  • Osteosarcoma, Somatic

  • Neoplasms, Bone Tissue

  • Bone Tissue Neoplasm

  • Osteoid Sarcoma

  • Skeletal Sarcoma

  • Osteosarcoma Of Bone

  • Bone Sarcoma
Epidermodysplasia Verruciformis 1

  • Epidermodysplasia Verruciformis

  • Epidermodysplasia Verruciformis, Susceptibility To, 1

  • Lutz-Lewandowsky Epidermodysplasia Verruciformis

  • EV1

  • Lewandowsky-Lutz Syndrome

  • Ev
Sensory System Disease
Eye Disease

  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-105024 FPL 62064 Inhibitor 99.25% Unkown
HY-N12231 Carbazomycin B Inhibitor / Unkown
HY-RS11729 RBL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RBL1 VGNC VGNC:69260
Bos taurus RBL1 VGNC VGNC:33781
Rattus norvegicus RBL1 RGD RGD:1595511
Mus musculus RBL1 MGD MGI:103300
Macaca mulatta RBL1 VGNC VGNC:76679
Canis familiaris RBL1 VGNC VGNC:45402
Others RBL1 NCBI