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RSU1 - Ras suppressor protein 1 Gene

Also Known as RSP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6251

About RSU1

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:16,590,611-16,817,424 (from NCBI)

This gene has 5 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in fat (RPKM 25.2), endometrium (RPKM 23.1) and 25 other tissues.

Summary

This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]

RSU1 Products (2)

mRNA	Protein	Name
NM_012425.4	NP_036557.1	ras suppressor protein 1 isoform 1
NM_152724.3	NP_689937.2	ras suppressor protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20926685	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20926685	GOA
involved in positive regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	20926685	GOA
NOT involved in regulation of cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	20926685	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	20926685	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RSU1 Protein Structure

LRR_8

LRR_1

LRR_4

0
100
200
277 a.a.

Protein Preferred Names	Protein Names
ras suppressor protein 1	rsu-1

RSU1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	RSU1	Q15404	LIMS1	Homo sapiens	P48059	Validated Y2H	25416956
Intra	RSU1	Q15404	LIMS1	Homo sapiens	P48059	Anti Tag CoIP	33961781
Intra	RSU1	Q15404	LIMS1	Homo sapiens	P48059	Anti Tag CoIP	28514442
Intra	RSU1	Q15404	LIMS1	Homo sapiens	P48059	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12313	RSU1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22314	Rsu1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28836	Rsu1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RSU1	VGNC	VGNC:97822
Bos taurus	RSU1	VGNC	VGNC:57022
Felis catus	RSU1	VGNC	VGNC:97615
Canis familiaris	RSU1	VGNC	VGNC:52921
Rattus norvegicus	RSU1	RGD	RGD:1591781
Mus musculus	RSU1	MGD	MGI:103040
Others	RSU1	NCBI