SFTPC - surfactant protein C Gene

Also Known as SP5; SP-C; PSP-C; SFTP2; SMDP2; BRICD6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6440

About SFTPC

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,157,383-22,164,479 (from NCBI)

This gene has 13 transcripts (splice variants), 115 orthologues and is associated with 6 phenotypes. Restricted expression toward lung (RPKM 8558.2).

Summary

This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.[provided by RefSeq, Feb 2010]

SFTPC Products (14)

mRNA	Protein	Name
NM_001172357.2	NP_001165828.1	pulmonary surfactant-associated protein C isoform 2
NM_001172410.2	NP_001165881.1	pulmonary surfactant-associated protein C isoform 1 precursor
NM_001317778.2	NP_001304707.1	pulmonary surfactant-associated protein C isoform 2
NM_001317779.2	NP_001304708.1	pulmonary surfactant-associated protein C isoform 3
NM_001317780.2	NP_001304709.1	pulmonary surfactant-associated protein C isoform 2
NM_001385653.1	NP_001372582.1	pulmonary surfactant-associated protein C isoform 1 precursor
NM_001385654.1	NP_001372583.1	pulmonary surfactant-associated protein C isoform 1 precursor
NM_001385655.1	NP_001372584.1	pulmonary surfactant-associated protein C isoform 1 precursor
NM_001385656.1	NP_001372585.1	pulmonary surfactant-associated protein C isoform 2
NM_001385657.1	NP_001372586.1	pulmonary surfactant-associated protein C isoform 2
NM_001385658.1	NP_001372587.1	pulmonary surfactant-associated protein C isoform 2
NM_001385659.1	NP_001372588.1	pulmonary surfactant-associated protein C isoform 2
NM_001385660.1	NP_001372589.1	pulmonary surfactant-associated protein C isoform 3
NM_003018.4	NP_003009.2	pulmonary surfactant-associated protein C isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19815549	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SFTPC Protein Structure

SP_C-Propep

BRICHOS

0
100
197 a.a.

Protein Preferred Names	Protein Names
pulmonary surfactant-associated protein C	BRICHOS domain containing 6

SFTPC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	SLC	25910212
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	26871637
Intra	SFTPC	P11686	SFTPC	Homo sapiens	P11686	Y2H Array	25910212
Intra	SFTPC	P11686	SFTPC	Homo sapiens	P11686	Y2H Array	32296183
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Validated Y2H	25910212
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Validated Y2H	26871637
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	31515488
Intra	SFTPC	P11686	SFTPC	Homo sapiens	P11686	Y2H Array	25416956
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Y2H Bait-Prey Pool	25910212
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Validated Y2H	32296183
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	25910212
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	26871637
Intra	SFTPC	P11686	SFTPC	Homo sapiens	P11686	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	25416956
Intra	SFTPC	P11686	SFTPC	Homo sapiens	P11686	Y2H Bait-Prey Pool	25910212
Intra	SFTPC	P11686	TMEM79	Homo sapiens	Q9BSE2	Y2H Array	32296183
Intra	SFTPC	P11686	SFTPC	Homo sapiens	P11686	Validated Y2H	25910212
Intra	SFTPC	P11686	SFTPC	Homo sapiens	P11686	Y2H Array	31515488
Intra	SFTPC	P11686	SFTPC	Homo sapiens	P11686	Validated Y2H	32296183
Intra	SFTPC	P11686	LSMEM2	Homo sapiens	Q8N112	Y2H Array	32296183
Intra	SFTPC	P11686	LSMEM2	Homo sapiens	Q8N112	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	LSMEM2	Homo sapiens	Q8N112	Validated Y2H	32296183
Intra	SFTPC	P11686	BSCL2	Homo sapiens	J3KQ12	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	BSCL2	Homo sapiens	J3KQ12	Y2H Array	32296183
Intra	SFTPC	P11686	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	SFTPC	P11686	GPX8	Homo sapiens	Q8TED1	Anti Tag CoIP	33961781
Intra	SFTPC	P11686	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	SFTPC	P11686	SYNE4	Homo sapiens	Q8N205-2	SLC	25910212
Intra	SFTPC	P11686	SYNE4	Homo sapiens	Q8N205-2	Validated Y2H	25910212
Intra	SFTPC	P11686	SYNE4	Homo sapiens	Q8N205-2	Y2H Bait-Prey Pool	25910212
Intra	SFTPC	P11686	SYNE4	Homo sapiens	Q8N205-2	Y2H Array	25910212
Intra	SFTPC	P11686	FNDC9	Homo sapiens	Q8TBE3	Validated Y2H	32296183
Intra	SFTPC	P11686	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	SFTPC	P11686	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	SFTPC	P11686	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	HPN	Homo sapiens	P05981	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	HPN	Homo sapiens	P05981	Y2H Array	32296183
Intra	SFTPC	P11686	CD200R1	Homo sapiens	Q8TD46-4	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	CD200R1	Homo sapiens	Q8TD46-4	Y2H Array	32296183
Intra	SFTPC	P11686	CD200R1	Homo sapiens	Q8TD46-4	Validated Y2H	32296183
Intra	SFTPC	P11686	SIGLEC9	Homo sapiens	Q9Y336	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	SIGLEC9	Homo sapiens	Q9Y336	Y2H Array	32296183
Intra	SFTPC	P11686	SIGLEC9	Homo sapiens	Q9Y336	Validated Y2H	32296183
Intra	SFTPC	P11686	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	SFTPC	P11686	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SFTPC	P11686	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	MUC1	Homo sapiens	P15941-11	Validated Y2H	32296183
Intra	SFTPC	P11686	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	SFTPC	P11686	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	GJA8	Homo sapiens	P48165	Validated Y2H	32296183
Intra	SFTPC	P11686	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	SFTPC	P11686	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	CPLX4	Homo sapiens	Q7Z7G2	Validated Y2H	32296183
Intra	SFTPC	P11686	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	SFTPC	P11686	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SFTPC	P11686	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	SFTPC	P11686	CLDN5	Homo sapiens	O00501	Y2H Array	32296183
Intra	SFTPC	P11686	CLDN5	Homo sapiens	O00501	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	TMEM106C	Homo sapiens	Q9BVX2	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	TMEM106C	Homo sapiens	Q9BVX2	Validated Y2H	32296183
Intra	SFTPC	P11686	TMEM106C	Homo sapiens	Q9BVX2	Y2H Array	32296183
Intra	SFTPC	P11686	IFNGR2	Homo sapiens	P38484	Validated Y2H	32296183
Intra	SFTPC	P11686	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	SFTPC	P11686	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	CXCL9	Homo sapiens	Q07325	Validated Y2H	32296183
Intra	SFTPC	P11686	CXCL9	Homo sapiens	Q07325	Y2H Prey Pooling	25416956
Intra	SFTPC	P11686	CXCL9	Homo sapiens	Q07325	Validated Y2H	25416956
Intra	SFTPC	P11686	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	SFTPC	P11686	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	PVR	Homo sapiens	P15151	Anti Tag CoIP	33961781
Intra	SFTPC	P11686	PVR	Homo sapiens	P15151	Validated Y2H	32296183
Intra	SFTPC	P11686	SEC61G	Homo sapiens	P60059	Validated Y2H	25416956
Intra	SFTPC	P11686	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212
Intra	SFTPC	P11686	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	SFTPC	P11686	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	SFTPC	P11686	GOLM1	Homo sapiens	Q8NBJ4	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	GOLM1	Homo sapiens	Q8NBJ4	Validated Y2H	32296183
Intra	SFTPC	P11686	GOLM1	Homo sapiens	Q8NBJ4	Y2H Array	32296183
Intra	SFTPC	P11686	SYNE4	Homo sapiens	Q8N205	Y2H Array	25416956
Intra	SFTPC	P11686	SYNE4	Homo sapiens	Q8N205	Y2H Prey Pooling	25416956
Intra	SFTPC	P11686	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	PDZK1IP1	Homo sapiens	Q13113	Validated Y2H	32296183
Intra	SFTPC	P11686	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	SFTPC	P11686	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	TMEM139	Homo sapiens	Q8IV31	Validated Y2H	32296183
Intra	SFTPC	P11686	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	SFTPC	P11686	ICAM3	Homo sapiens	P32942	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	ICAM3	Homo sapiens	P32942	Validated Y2H	32296183
Intra	SFTPC	P11686	ICAM3	Homo sapiens	P32942	Y2H Array	32296183
Intra	SFTPC	P11686	SMIM3	Homo sapiens	Q9BZL3	Y2H Bait-Prey Pool	25910212
Intra	SFTPC	P11686	SMIM3	Homo sapiens	Q9BZL3	Validated Y2H	25910212
Intra	SFTPC	P11686	SMIM3	Homo sapiens	Q9BZL3	SLC	25910212
Intra	SFTPC	P11686	SMIM3	Homo sapiens	Q9BZL3	Y2H Array	25910212
Intra	SFTPC	P11686	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	SFTPC	P11686	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	SFTPC	P11686	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	SEC22A	Homo sapiens	Q96IW7	Y2H Prey Pooling	25416956
Intra	SFTPC	P11686	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183
Intra	SFTPC	P11686	KLRC1	Homo sapiens	P26715	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	KLRC1	Homo sapiens	P26715	Validated Y2H	32296183
Intra	SFTPC	P11686	KLRC1	Homo sapiens	P26715	Y2H Array	32296183
Intra	SFTPC	P11686	TMEM30B	Homo sapiens	Q3MIR4	Y2H Prey Pooling	32296183
Intra	SFTPC	P11686	TMEM30B	Homo sapiens	Q3MIR4	Validated Y2H	32296183
Intra	SFTPC	P11686	TMEM30B	Homo sapiens	Q3MIR4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Surfactant Metabolism Dysfunction, Pulmonary, 2	Interstitial Lung Disease Due To Surfactant Protein C Deficiency SMDP2 Desquamative Interstitial Pneumonitis Due To Surfactant Protein C Deficiency Pulmonary Alveolar Proteinosis, Congenital, 2 Chronic Respiratory Distress With Surfactant Metabolism Deficiency Interstitial Lung Disease Due To Sp-C Deficiency Pulmonary Surfactant Metabolism Dysfunction 2 Congenital Pulmonary Alveolar Proteinosis 2 Pap Surfactant Metabolism Dysfunction, Pulmonary, Type 2
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Interstitial Lung Disease	Ild Lung Diseases, Interstitial Lung Diseases Interstitial Interstitial Lung Diseases
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Pulmonary Alveolar Proteinosis
Respiratory Distress Syndrome In Premature Infants	Hyaline Membrane Disease Infant Respiratory Distress Syndrome Rds Of Prematurity Hyaline Membrane Disease, Formerly Infant Acute Respiratory Distress Syndrome Infant Ards Neonatal Respiratory Distress Syndrome Respiratory Distress Syndrome, Infant RDS Rds In Prematurity Respiratory Distress Syndrome, Newborn Rds - Infants
Newborn Respiratory Distress Syndrome	Hyaline Membrane Disease Respiratory Distress Syndrome Of Newborn Neonatal Respiratory Distress Hmd - Hyaline Membrane Disease Neonatal Respiratory Distress Syndrome Pulmonary Hyaline Membrane Disease Pulmonary Hypoperfusion Syndrome Of Newborn Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome Cardiorespiratory Distress Syndrome Of Newborn Distress Respiratory Syndrome Newborn Idiopathic Respiratory Distress Syndrome Idiopathic Respiratory Distress Syndrome Of Newborn Newborn Idiopathic Respiratory Distress Syndrome Respiratory Distress Syndrome In Newborn Rds - [Respiratory Distress Syndrome] Of Newborn Newborn Cardiorespiratory Distress Syndrome
Skeletal Muscle Disease
Adult Respiratory Distress Syndrome	Acute Respiratory Distress Syndrome Ards Non-Cardiogenic Pulmonary Edema Acute Lung Injury Respiratory Distress Syndrome, Adult Shock Lung Acute Respiratory Distress Respiratory Distress Syndrome Adult Rds Ali Increased-Permeability Pulmonary Edema Stiff Lung Respiratory Distress Syndrome Adult
Pulmonary Fibrosis	Fibrosis Of Lung
Protein C Deficiency	Hereditary Thrombophilia Due To Protein C Deficiency Proc Deficiency Congenital Thrombotic Disease, Due To Protein C Deficiency
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Respiratory Disease Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Neonatal Respiratory Failure	Respiratory Failure Of Newborn Inadequate Pulmonary Ventilation Of Newborn Newborn Lung Insufficiency Newborn Pulmonary Function Inadequate Newborn Pulmonary Insufficiency Newborn Respiration Failure Newborn Respiratory Insufficiency Respiratory Insufficiency Syndrome Of Newborn
Interstitial Pneumonitis, Desquamative, Familial	Desquamative Interstitial Pneumonia DIP Pneumonitis, Desquamative Interstitial, Familial Pneumonia, Desquamative Interstitial, Familial Interstitial Lung Disease, Desquamative Ild, Desquamative Familial Desquamative Interstitial Pneumonitis Rbild Respiratory Bronchiolitis-Associated Interstitial Lung Disease Respiratory Bronchiolitis Associated Interstitial Lung Disease
Lung Benign Neoplasm	Lung Neoplasms Tumor Of The Lung Lung Tumor
Pulmonary Interstitial Emphysema
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Pneumonia	Acute Pneumonia Pneumonias Infectious Pneumonia Pn - [Pneumonia] Lobar Pneumonia Nos Multifocal Pneumonia Orthostatic Pneumonia Pneumonia Nos Chronic Pneumonia Nos Atypical Pneumonia Passive Pneumonia Purulent Pneumonia Interstitial Lobar Pneumonia Pneumonia, Unspecified Pneumonia Due To Chlamydia Pneumonia Due To Chlamydia Pneumoniae Pneumonia Due To E. Coli Escherichia Coli Lobar Pneumonia Pneumonia Due To H. Influenzae Pneumonia Due To Hemophilus Influenzae Bronchopneumonia Due To H. Influenzae Haemophilus Influenzae Lobar Pneumonia Bronchopneumonia Due To Hemophilus Influenzae Pseudomonal Pneumonia Pseudomonas Pneumonia Pseudomonas Lobar Pneumonia Staphylococcal Pneumonia Staphylococcus Pneumonia Acute Staphylococcal Pneumonia Staphylococcal Double Pneumonia Staphylococcal Lobar Pneumonia Staphylococcal Purulent Pneumonia Staphylococcal Bronchopneumonia Pneumococcal Pneumonia Pneumococcus Pneumonia Bronchopneumonia Due To S. Pneumoniae Pneumococcal Lobar Pneumonia Streptococcal Pneumoniae Pneumonia Streptococcus Pneumoniae Lobar Pneumonia Pyemic Pneumococcal Embolism With Pneumonia Bronchopneumonia Due To Streptococcus Pneumoniae Pneumonia Due To Streptococcus, Group B Group B Streptococcal Pneumonia Adenovirus Pneumonia Adenoviral Pneumonia Adenovirus Viral Pneumonia Pneumonia Respiratory Syncytial Viral Parainfluenza Viral Pneumonia Parainfluenzal Pneumonia Parainfluenza Virus Pneumonia Human Metapneumovirus Pneumonia Human Metapneumovirus Infection Resulting In Pneumonia Pneumocystis Pneumonia Plasma Cells Pneumonia
Nonspecific Interstitial Pneumonia	Nsip Non-Specific Interstitial Pneumonia Non-Specific Idiopathic Interstitial Pneumonia Non-Specific Interstitial Pneumonia Nos
Pulmonary Emphysema
Myopathy	Muscular Diseases Myopathies
Idiopathic Interstitial Pneumonia	Hamman-Rich Syndrome Diffuse Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis Ipf Idiopathic Interstitial Pneumonias Idiopathic Interstitial Pneumonia, Not Otherwise Specified Pulmonary Fibrosis
Pulmonary Immaturity	Primary Atelectasis Of Newborn Primary Atelectasis, In Perinatal Period Primary Failure To Expand Terminal Respiratory Units Immature Lungs Primary Atelectasis Pulmonary Immaturity Nos Lung Lobe Hypoplasia, Associated With Short Gestation Lung Nonexpansion Premature Lungs Pulmonary Hypoplasia Associated With Short Gestation Failure Of Expansion Of Terminal Respiratory Units Primary Atelectasis Of Fetus Or Newborn Primary Atelectasis In Perinatal Period
Papillary Adenoma	Glandular Papilloma Adenoma
Bronchial Benign Neoplasm	Bronchus Neoplasm Neoplasm Of Bronchus Bronchial Neoplasms Bronchial Neoplasm
Large Cell Carcinoma	Carcinoma, Large Cell Carcinoma Large Cell
Alveoli Adenoma	Alveolar Adenoma Adenoma Of Alveoli Adenoma Of The Alveoli
Adenosquamous Carcinoma	Adenosquamous Cell Carcinoma Mixed Adenocarcinoma And Squamous Carcinoma Carcinoma Adenosquamous Carcinoma, Adenosquamous
Lung Adenoma	Adenoma Of Lung Pulmonary Adenoma
Respiratory System Benign Neoplasm
Pulmonary Hemosiderosis	Idiopathic Pulmonary Hemosiderosis Alveolar Hypoventilation Syndrome Brown Induration Brown Lung Siderosis Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin Byssinosis
Acute Interstitial Pneumonia	Acute Interstitial Pneumonitis Hamman-Rich Syndrome Accelerated Interstitial Pneumonia Aip Hamman-Rich Disease Idiopathic Pulmonary Fibrosis, Acute Fatal Form Idiopathic Pulmonary Fibrosis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Cryptogenic Organizing Pneumonia	Bronchiolitis Obliterans Organizing Pneumonia Boop Constrictive Bronchiolitis Cryptogenic Organizing Pneumonitis Cop Bronchiolitis Obliterans Organising Pneumonia Cryptogenic Organising Pneumonia Cryptogenic Organising Pneumonitis Idiopathic Bronchiolitis Obliterans With Organising Pneumonia Idiopathic Bronchiolitis Obliterans With Organizing Pneumonia Organizing Pneumonia Idiopathic Boop Idiopathic Bronchiolitis Obliterans Organizing Pneumonia Organized Pneumonia
Lipid Pneumonia	Exogenous Lipoid Pneumonia Lipoid Pneumonitis Pneumonia, Lipid Pneumonia Lipid Lipoid Pneumonia
Diaphragm Disease	Abnormality Of The Diaphragm Disease Of Diaphragm Diaphragmatic Disorder Disorder Of Diaphragm
Chronic Congestive Splenomegaly
Pulmonary Adenocarcinoma In Situ	Bronchioalveolar Carcinoma
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Lung Carcinoma In Situ
Diaphragmatic Hernia, Congenital	Congenital Diaphragmatic Hernia Diaphragmatic Hernia Cdh Congenital Diaphragmatic Defect Hernia, Diaphragmatic Dih Hernia, Congenital Diaphragmatic Hcd Diaphragmatic Defect, Congenital Diaphragm, Unilateral Agenesis Of Hemidiaphragm, Agenesis Of Diaphragmatic Hernia 1 Agenesis Of Hemidiaphragm Unilateral Agenesis Of Diaphragm Hernia Diaphragmatic Hernia Diaphragmatic Congenital Hernia, Diaphragmatic, Type 1 Hiatus Hernia Oesophageal Hiatus Hernia Paraoesophageal Hernia Sliding Hiatus Hernia Congenital Diaphragm Hernia Congenital Diaphragm Defect With Hernia Gross Congenital Diaphragm Defect
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS12783	SFTPC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21754	Sftpc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28272	Sftpc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SFTPC	VGNC	VGNC:34529
Rattus norvegicus	SFTPC	RGD	RGD:3666
Mus musculus	SFTPC	MGD	MGI:109517
Felis catus	SFTPC	VGNC	VGNC:65067
Macaca mulatta	SFTPC	VGNC	VGNC:84113
Canis familiaris	SFTPC	VGNC	VGNC:54994
Others	SFTPC	NCBI