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HSP90B1 - heat shock protein 90 beta family member 1 Gene

Also Known as ECGP; GP96; TRA1; GRP94; HEL35; HEL-S-125m

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7184

About HSP90B1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:103,930,410-103,947,926 (from NCBI)

This gene has 35 transcripts (splice variants), 224 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 807.9), appendix (RPKM 260.4) and 24 other tissues.

Summary

This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding Other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a MicroRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]

HSP90B1 Products (1)

mRNA	Protein	Name
NM_003299.3	NP_003290.1	endoplasmin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables RNA binding	IDA IDA: Inferred from direct assay	11958450	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9596688	GOA
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	19000834	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	18264092	GOA
acts upstream of or within actin rod assembly	IDA IDA: Inferred from direct assay	19000834	GOA
acts upstream of or within cellular response to ATP	IDA IDA: Inferred from direct assay	19000834	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10497210	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	15620698	GOA
involved in retrograde protein transport, ER to cytosol	IMP IMP: Inferred from mutant phenotype	25660456	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytosol	IDA IDA: Inferred from direct assay	9596688	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17344063	GOA
located in endoplasmic reticulum lumen	IDA IDA: Inferred from direct assay	10497210	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10497210	GOA
located in midbody	IDA IDA: Inferred from direct assay	15166316	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10497210	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23349634	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSP90B1 Protein Structure

HATPase_c_3

HSP90

0
200
400
600
803 a.a.

Protein Preferred Names	Protein Names
endoplasmin	94 kDa glucose-regulated protein

HSP90B1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	HSP90B1	P14625	HSPA5	Homo sapiens	P11021	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

HSP90B1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P82774	GRP94 Antibody (YA2519)	WB, IHC-P, ICC/IF	Human, Mouse
HY-P86194	GRP94 Antibody (YA5886)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pelizaeus-Merzbacher-Like Disease	Pmld
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Platyspondylic Lethal Skeletal Dysplasia, Torrance Type	PLSD-T PLSDT Platyspondylic Dysplasia, Torrance Type Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type Thanatophoric Dysplasia, Torrance Variant Platyspondylic Skeletal Dysplasia, Torrance Type Torrance Type Platyspondylic Dysplasia Platyspondylic Dysplasia, Torrance-Luton Type Platyspondylic Lethal Skeletal Dysplasia Torrance Type Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type Thanatophoric Dysplasia Torrance Variant Platyspondylic Chondrodysplasia, Torrance-Luton Type Plsd-Tl Dysplasia, Skeletal, Platyspondylic, Torrance Type
Pseudoachondroplasia	PSACH Pseudoachondroplastic Dysplasia Pseudoachondroplastic Spondyloepiphyseal Dysplasia Syndrome Spondyloepiphyseal Dysplasia, Pseudoachondroplastic Pseudoachondroplastic Spondyloepiphyseal Dysplasia Spondyloepiphyseal Dysplasia Pseudoachondroplastic
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-10214	SNX-2112		99.49%	Unkown
HY-N2445	Flavokawain C		99.79%	Unkown
HY-170820	XYD049	Inhibitor	99.46%	Unkown
HY-RS06419	HSP90B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21240	Hsp90b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27757	Hsp90b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HSP90B1	MGD	MGI:98817
Felis catus	HSP90B1	VGNC	VGNC:84033
Bos taurus	HSP90B1	VGNC	VGNC:49984
Rattus norvegicus	HSP90B1	RGD	RGD:1310482
Macaca mulatta	HSP90B1	VGNC	VGNC:97776
Canis familiaris	HSP90B1	VGNC	VGNC:54212
Others	HSP90B1	NCBI