DHX58 - DExH-box helicase 58 Gene

Also Known as LGP2; RLR-3; D11LGP2; D11lgp2e

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79132

About DHX58

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,101,411-42,112,714 (from NCBI)

This gene has 8 transcripts (splice variants), 242 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 10.6), testis (RPKM 8.8) and 25 other tissues.

Summary

Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DHX58 Products (1)

mRNA	Protein	Name
NM_024119.3	NP_077024.2	ATP-dependent RNA helicase DHX58

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables RNA helicase activity	IMP IMP: Inferred from mutant phenotype	19211564	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	18411269	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17190814	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	18411269	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	19278996	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cytoplasmic pattern recognition receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19211564	GOA
involved in negative regulation of MDA-5 signaling pathway	IMP IMP: Inferred from mutant phenotype	21187438	GOA
involved in negative regulation of RIG-I signaling pathway	IDA IDA: Inferred from direct assay	18411269	GOA
involved in negative regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	21187438	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	21525357	GOA
involved in negative regulation of type I interferon production	IDA IDA: Inferred from direct assay	21525357	GOA
involved in regulation of innate immune response	IDA IDA: Inferred from direct assay	18411269	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DHX58 Protein Structure

ResIII

Helicase_C

RIG-I_C-RD

0
200
400
600
678 a.a.

Protein Preferred Names	Protein Names
ATP-dependent RNA helicase DHX58 probable ATP-dependent RNA helicase DHX58	ATP-dependent helicase LGP2

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DHX58

probable ATP-dependent RNA helicase DHX58

ATP-dependent helicase LGP2

DHX58 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	DHX58	Q96C10	DHX30	Homo sapiens	Q7L2E3	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	EIF6	Homo sapiens	P56537	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	EIF2AK2	Homo sapiens	P19525	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	STAU2	Homo sapiens	Q9NUL3	Anti Tag CoIP	21903422
Intra	DHX58	Q96C10	NKRF	Homo sapiens	O15226	Anti Tag CoIP	21903422
Cross	DHX58	Q96C10	P/V	Simian virus 5	P11207	Anti Tag CoIP	19403670
Cross	DHX58	Q96C10	P/V	Measles virus	Q9EMA9	Anti Tag CoIP	19403670

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Measles	Rubeola Morbilli Measles Nos Koplik Spots
Rabies	Lyssa Hydrophobia St Hubert Disease
Ileum Cancer	Ileal Neoplasm Malignant Neoplasm Of Ileum Ileal Cancer Ileal Neoplasms
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Keratitis, Hereditary	Keratitis Autosomal Dominant Keratitis Hereditary Keratitis Dominantly Inherited Keratitis Keratitis Hereditary KERH

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS03759	DHX58 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21554	Dhx58 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28072	Dhx58 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DHX58	VGNC	VGNC:39951
Rattus norvegicus	DHX58	RGD	RGD:1310093
Macaca mulatta	DHX58	VGNC	VGNC:71815
Mus musculus	DHX58	MGD	MGI:1931560
Felis catus	DHX58	VGNC	VGNC:61486
Bos taurus	DHX58	VGNC	VGNC:28058
Others	DHX58	NCBI