EIF3C - eukaryotic translation initiation factor 3 subunit C Gene

Also Known as EIF3CL; EIF3S8; eIF3-p110

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8663

About EIF3C

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,688,558-28,735,730 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues.

Summary

Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of mRNA binding activity; positive regulation of translation; and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]

EIF3C Products (5)

mRNA Protein Name
NM_001037808.2 NP_001032897.1 eukaryotic translation initiation factor 3 subunit C isoform a
NM_001199142.1 NP_001186071.1 eukaryotic translation initiation factor 3 subunit C isoform a
NM_001267574.2 NP_001254503.1 eukaryotic translation initiation factor 3 subunit C isoform a
NM_001286478.1 NP_001273407.1 eukaryotic translation initiation factor 3 subunit C isoform b
NM_003752.5 NP_003743.1 eukaryotic translation initiation factor 3 subunit C isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
10504338 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
8995409 GOA
contributes to translation initiation factor activity IDA
IDA: Inferred from direct assay
17581632 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of mRNA binding IPI
IPI: Inferred from physical interaction
24092755 GOA
involved in positive regulation of translation IPI
IPI: Inferred from physical interaction
24092755 GOA
involved in translational initiation IDA
IDA: Inferred from direct assay
17581632 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of eukaryotic translation initiation factor 3 complex IDA
IDA: Inferred from direct assay
17322308 GOA
part of eukaryotic translation initiation factor 3 complex IPI
IPI: Inferred from physical interaction
17322308 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3C Protein Structure

eIF-3c_N

eIF-3c_N: Eukaryotic translation initiation factor 3 subunit 8 N-terminus (31 - 230)

eIF-3c_N

eIF-3c_N: Eukaryotic translation initiation factor 3 subunit 8 N-terminus (264 - 705)

PCI

PCI: PCI domain (713 - 846)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 913 a.a.
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 3 subunit C

  • cell migration-inducing protein 17

EIF3C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
EIF3C Q99613 UBE3A Homo sapiens Q05086-2
Anti Tag CoIP
29426014
Intra
EIF3C Q99613 EIF1AX Homo sapiens P47813
Pull Down
23623729
Intra
EIF3C Q99613 EIF3E Homo sapiens P60228
Y2H
10504338
Intra
EIF3C Q99613 EIF3E Homo sapiens P60228
SLCA
18599441
Intra
EIF3C Q99613 EIF3E Homo sapiens P60228
Anti Tag CoIP
33961781
Intra
EIF3C Q99613 EIF3A Homo sapiens Q14152
Anti Tag CoIP
33961781
Cross
EIF3C Q99613 ORF Human immunodeficiency virus Q9Q2G4
Pull Down
22190034
Intra
EIF3C Q99613 EIF1 Homo sapiens P41567
Pull Down
23623729
Intra
EIF3C Q99613 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04259 EIF3C Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus EIF3C MGD MGI:1926966
Rattus norvegicus EIF3C RGD RGD:1308871