COPS2 - COP9 signalosome subunit 2 Gene

Also Known as CSN2; SGN2; ALIEN; TRIP15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9318

About COPS2

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:49,122,727-49,155,599 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 22.3), thyroid (RPKM 19.6) and 25 other tissues.

Summary

Predicted to enable transcription corepressor activity. Involved in protein deneddylation and protein phosphorylation. Located in cytoplasm. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Apr 2022]

COPS2 Products (2)

mRNA Protein Name
NM_001143887.2 NP_001137359.1 COP9 signalosome complex subunit 2 isoform 2
NM_004236.4 NP_004227.1 COP9 signalosome complex subunit 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
17438371 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in protein deneddylation IDA
IDA: Inferred from direct assay
19141280 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9535219 GOA
Cellular Component GO Annotation Evidence Verweise Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
9535219 GOA
part of COP9 signalosome IPI
IPI: Inferred from physical interaction
25043011 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
9535219 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24421388 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS2 Protein Structure

PCI

PCI: PCI domain (310 - 411)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 443 a.a.
Protein Preferred Names Protein Names

COP9 signalosome complex subunit 2

  • COP9 constitutive photomorphogenic homolog subunit 2

COPS2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
COPS2 P61201 GPS1 Homo sapiens Q13098-7
Y2H Prey Pooling
32296183
Intra
COPS2 P61201 GPS1 Homo sapiens Q13098-7
Validated Y2H
32296183
Intra
COPS2 P61201 GPS1 Homo sapiens Q13098-7
Y2H Array
32296183
Intra
COPS2 P61201 GPS1 Homo sapiens Q13098-7
X-Ray Diffraction
25043011
Intra
COPS2 P61201 GPS1 Homo sapiens Q13098-7
GMS
25043011
Cross
COPS2 P61201 Crebbp Mus musculus P45481
Pull Down
23441852
Intra
COPS2 P61201 COPS3 Homo sapiens Q9UNS2
GMS
25043011
Intra
COPS2 P61201 COPS3 Homo sapiens Q9UNS2
Anti Tag CoIP
33961781
Intra
COPS2 P61201 COPS3 Homo sapiens Q9UNS2
X-Ray Diffraction
25043011
Intra
COPS2 P61201 PSMD11 Homo sapiens O00231
Y2H Prey Pooling
32296183
Intra
COPS2 P61201 PSMD11 Homo sapiens O00231
Y2H Array
32296183
Intra
COPS2 P61201 EP300 Homo sapiens Q09472
Acetylase Assay
23441852
Intra
COPS2 P61201 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
COPS2 P61201 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
COPS2 P61201 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
COPS2 P61201 ZNF446 Homo sapiens Q9NWS9-2
Validated Y2H
32296183
Intra
COPS2 P61201 NDUFV1 Homo sapiens P49821
Y2H Array
32814053
Intra
COPS2 P61201 NDUFV1 Homo sapiens P49821
Y2H Pooling
32814053
Intra
COPS2 P61201 NDUFV1 Homo sapiens P49821
Validated Y2H
32814053
Intra
COPS2 P61201 CREBBP Homo sapiens Q92793
Anti Bait CoIP
23441852
Cross
COPS2 P61201 P29991-PRO_0000037946 Dengue virus type 2 P29991-PRO_0000037946
Y2H
21911577
Cross
COPS2 P61201 P29991-PRO_0000037946 Dengue virus type 2 P29991-PRO_0000037946
Split-Luc
21911577
Cross: Cross-species interaction Intra: Intraspecies interaction

COPS2 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P811276 COPS2 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Xeroderma Pigmentosum, Complementation Group E

  • Xeroderma Pigmentosum V

  • Xp5

  • Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

  • Xpe

  • Xp, Group E

  • Xeroderma Pigmentosum, Type 5

  • Xeroderma Pigmentosum Complementation Group E

  • XP-E

  • Xp Group E
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03027 COPS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris COPS2 VGNC VGNC:39509
Macaca mulatta COPS2 VGNC VGNC:71376
Mus musculus COPS2 MGD MGI:1330276
Bos taurus COPS2 VGNC VGNC:27599
Rattus norvegicus COPS2 RGD RGD:628791
Felis catus COPS2 VGNC VGNC:61087
Others COPS2 NCBI