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Art. -Nr.: HY-45854

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GWP-042

2 Cited Publications

Kundenbewertung

Based on 2 publication(s) in Google Scholar

GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC₅₀ of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo.

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Reinheit: 95.63%
CAS. Nr.: 1645486-93-6
Formel: C₁₄H₁₅FN₄O₂
Molecular Weight:290.29

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

GWP-042 Chemical Structure

CAS. Nr.: 1645486-93-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
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Bioz

Biologische Aktivität

Beschreibung

GWP-042 is a potent inhibitor of mycobacterial alanine dehydrogenase (Ald) Rv2780, with the IC₅₀ of 0.21 μM. GWP-042 has antimicrobial activity against M. tuberculosis infection in vivo^[1].

Chemical Information

CAS. Nr. 1645486-93-6
Appearance Solid
Molecular Weight 290.29
Formel C₁₄H₁₅FN₄O₂
Color White to off-white
SMILES

O=C([C@@H]1CCCO1)NC2=NN=C(N2)CC3=CC(F)=CC=C3
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Nat Commun

Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine. [Abstract]

2024 May 17;15(1):4216. PMID: 38760394
Research Square Preprint

2023 Sep 22.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : < 0.1 mg/mL (insoluble)

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Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cheng Peng, et al. Mycobacterium tuberculosis suppresses host antimicrobial peptides by dehydrogenating L-alanine. Nat Commun. 2024 May 17;15(1):4216.c [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

GWP-042

2 Cited Publications

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Biologische Aktivität
- Beschreibung
Chemical Information
Publications (2)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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GWP-042

Publications Citing Use of MedChemExpress (MCE) GWP-042

Biologische Aktivität

Chemical Information

Publications (2)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

GWP-042 Related Classifications

HY-45854 Related Classifications