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Art. -Nr.: HY-187378

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HPPD-IN-12

HPPD-IN-12 is an inhibitor of Arabidopsis thaliana 4-hydroxyphenylpyruvate dioxygenase (AtHPPD), with an IC₅₀ of 27.8 μM and a K_d of 1.535 μM. HPPD-IN-12 binds to AtHPPD via Fe²⁺ coordination, π-π interactions and hydrogen bonds. HPPD-IN-12 can be used in herbicide-related research.

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CAS. Nr.: 3124322-98-8
Formel: C₂₁H₂₄N₄O₆
Molecular Weight:428.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

HPPD-IN-12 Chemical Structure

CAS. Nr.: 3124322-98-8

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

In Vitro

HPPD-IN-12 (compound B18) inhibits AtHPPD with an IC₅₀ of 27.8 μM; its dissociation constant is 1.535 μM, and it exhibits stronger affinity than Bentazone (HY-B2039)^[1].
HPPD-IN-12 (0-22 μM) binds to AtHPPD with an association constant of 1.0 × 10^4.157 M^-1, and its affinity is stronger than that of Topramezone (HY-144900)^[1].
HPPD-IN-12 stably binds to AtHPPD^[1] through Fe²⁺ chelation, π-π stacking, and hydrogen bonding interactions with amino acid residues at key active sites.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3124322-98-8
Molecular Weight 428.44
Formel C₂₁H₂₄N₄O₆
SMILES

CCOC(OC(C)OC(N(C)N=C1C)=C1C(C2=CC=C(N=C(C)C(N3C)=O)C3=C2)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Liu L, et al. Novel Pyrazole-Quinoxaline Conjugates as Potent HPPD-Inhibiting Herbicides with Notable Crop Safety. Journal of agricultural and food chemistry. 2026 Jul 22;74(28):21818-21828. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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