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Art. -Nr.: HY-157084

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HS-291

HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb). HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin).HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb.

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Formel: C₁₅₆H₁₉₄N₁₈O₃₆S₂
Molecular Weight:2961.44

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

HS-291 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

HS-291 (0.1-10 μM, 24 h) inhibits Bb culture viability when excited with nrIR (Ex: 693nm 5 J/cm²)^[1].
HS-291 (10 μM, 90 min) can specifically target Bb in Bb culture^[1].
HS-291 (0-10 μM, 24 h) causes cell wall blebbing, nucleoid condensation and loss of cell wall integrity of cells when excited with nrIR (Ex: 693nm 5 J/cm²)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 2961.44
Formel C₁₅₆H₁₉₄N₁₈O₃₆S₂
SMILES

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC1=CC=C(N2C(C3=C(O)C=C(O)C(C(C)C)=C3)=NNC2=S)C=C1)=O)CCC4=C(/C=C5C(CCC(OC)=O)=C(C(/C=C6N/C(C(C)=C\6C=C)=C\C(C7=CC=C(C(OC)=O)[C@@H](C(OC)=O)[C@]7/8C)=NC8=C/9)=N/5)C)NC9=C4C.CC(CCC%10=C%11NC(/C=C([C@@]%12%13C)\N=C(C%12=CC=C([C@H]%13C(OC)=O)C(OC)=O)/C=C(C(C)=C/%14C=C)\NC%14=C/C(C(C)=C/%15CCC(ONCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCC%16=CC=C(C=C%16)N%17C(NN=C%17C%18=C(C=C(C(C(C)C)=C%18)O)O)=S)=O)=O)=NC%15=C/%11)=C%10C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Carlson DL, et al. Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development. Cell Chem Biol. 2023 Nov 1:S2451-9456(23)00340-9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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