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Art. -Nr.: HY-146811

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HSGN-94

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HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.80%
CAS. Nr.: 2570797-85-0
Formel: C₂₃H₂₃F₃N₄O₄S
Molecular Weight:508.51

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

HSGN-94 Chemical Structure

CAS. Nr.: 2570797-85-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

HSGN-94 (50 μM; 30 min) directly binds to CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (PgsA)^[1].
HSGN-94 (0.25 μg/mL; 2 h) downregulates the expression level of PgsA, an essential protein for phospholipid synthesis in the bacteria S. aureus^[1].
HSGN-94 (16, 32, 64, and 128 μg/mL; 2 h) is not toxic to HaCat cells at concentrations up to 64 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HSGN-94 (2%; external use; twice daily for 5 days) decreases MRSA USA300 in infected wounds of mice and results resolution of inflammation in infection model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MRSA murine wound infection model^[1]
Dosage:

2%
Administration:

External use; twice daily for 5 days
Result:

Reduced the levels of the pro-inflammatory cytokines, monocyte chemo attractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), and interleukin-1 beta (IL-1β) in MRSA USA300 skin lesions.

Chemical Information

CAS. Nr. 2570797-85-0
Appearance Solid
Molecular Weight 508.51
Formel C₂₃H₂₃F₃N₄O₄S
Color White to off-white
SMILES

O=S(C1=CC=C(C=C1)C(NC2=NN=C(O2)C3=CC=C(C=C3)C(F)(F)F)=O)(N4C[C@@H](C[C@@H](C4)C)C)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (196.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9665 mL

9.8326 mL

19.6653 mL

5 mM

0.3933 mL

1.9665 mL

3.9331 mL

10 mM

0.1967 mL

0.9833 mL

1.9665 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Naclerio GA, et al. Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic. J Med Chem. 2022 May 12;65(9):6612-6630. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9665 mL	9.8326 mL	19.6653 mL	49.1632 mL
	5 mM	0.3933 mL	1.9665 mL	3.9331 mL	9.8326 mL
	10 mM	0.1967 mL	0.9833 mL	1.9665 mL	4.9163 mL
	15 mM	0.1311 mL	0.6555 mL	1.3110 mL	3.2775 mL
	20 mM	0.0983 mL	0.4916 mL	0.9833 mL	2.4582 mL
	25 mM	0.0787 mL	0.3933 mL	0.7866 mL	1.9665 mL
	30 mM	0.0656 mL	0.3278 mL	0.6555 mL	1.6388 mL
	40 mM	0.0492 mL	0.2458 mL	0.4916 mL	1.2291 mL
	50 mM	0.0393 mL	0.1967 mL	0.3933 mL	0.9833 mL
	60 mM	0.0328 mL	0.1639 mL	0.3278 mL	0.8194 mL
	80 mM	0.0246 mL	0.1229 mL	0.2458 mL	0.6145 mL
	100 mM	0.0197 mL	0.0983 mL	0.1967 mL	0.4916 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

Produktname:
Art. -Nr.:
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MCE Japan Authorized Agent:

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HSGN-94

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Antibacterial Compound Library

Anti-Drug-Resistant Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

HSGN-94

Anti-Infection Compound Library

Immunology/Inflammation Compound Library

Antibacterial Compound Library

Anti-Drug-Resistant Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

HSGN-94 Related Classifications

HY-146811 Related Classifications