IMM-H012
IMM-H012 is a specific PI3K inhibitor with an IC50 of 0.80 nM against PI3Kα. IMM-H012 combined with [177Lu]Lu-P4 shows synergistic antitumor effects against stomach cancer and lung cancer.
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- CAS. Nr.: 2231399-03-2
- Formel: C26H25F2N5O5S
- Molecular Weight:557.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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PI3K 0.80 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.053 μM
Compound: 19
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Cytotoxicity against human A549 cells after 96 hrs by MTT assay
Cytotoxicity against human A549 cells after 96 hrs by MTT assay
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[PMID: 29927604] |
IMM-H012 potently inhibits PI3Kα kinase activity with an IC50 of 0.80 nM[1].
IMM-H012 (IC50 of 0.514 μM) inhibits MKN-45 gastric cancer cell proliferation[1].
IMM-H012 modulates PI3K pathway gene expression in MKN-45 cells by downregulating PIK3CA and PIK3CB while upregulating compensatory PIK3CD and PIK3R3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2231399-03-2
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Molecular Weight 557.57
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Formel C26H25F2N5O5S
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SMILES
CC1=NC(N)=NC2=C1C=C(C3=CC(NS(C4=C(F)C=C(F)C=C4)(=O)=O)=C(OC)N=C3)C=C2OC5CCOCC5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IMM-H012 Related Classifications
HY-181581 Related Classifications
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