IMM-H012
IMM-H012 is a specific PI3K inhibitor with an IC50 of 0.80 nM against PI3Kα. IMM-H012 combined with [177Lu]Lu-P4 shows synergistic antitumor effects against stomach cancer and lung cancer.
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- CAS. Nr.: 2231399-03-2
- Formel: C26H25F2N5O5S
- Molecular Weight:557.57
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PI3K 0.80 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.053 μM
Compound: 19
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Cytotoxicity against human A549 cells after 96 hrs by MTT assay
Cytotoxicity against human A549 cells after 96 hrs by MTT assay
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[PMID: 29927604] |
In Vitro
IMM-H012 potently inhibits PI3Kα kinase activity with an IC50 of 0.80 nM[1].
IMM-H012 (IC50 of 0.514 μM) inhibits MKN-45 gastric cancer cell proliferation[1].
IMM-H012 modulates PI3K pathway gene expression in MKN-45 cells by downregulating PIK3CA and PIK3CB while upregulating compensatory PIK3CD and PIK3R3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 2231399-03-2
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Molecular Weight 557.57
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Formel C26H25F2N5O5S
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SMILES
CC1=NC(N)=NC2=C1C=C(C3=CC(NS(C4=C(F)C=C(F)C=C4)(=O)=O)=C(OC)N=C3)C=C2OC5CCOCC5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IMM-H012 Related Classifications
HY-181581 Related Classifications
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