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Art. -Nr.: HY-111003

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Isothiafludine

(Synonyms: NZ-4)

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Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.87%
CAS. Nr.: 960527-22-4
Formel: C₁₈H₁₈FN₃OS₂
Molecular Weight:375.48

Speicherung:

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Isothiafludine Chemical Structure

CAS. Nr.: 960527-22-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isothiafludine is an orally active non-nucleosidic anti-HBV compound. Isothiafludine inhibits hepatitis B virus replication by blocking pregenomic RNA encapsidation^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	29 μM Compound: NZ-4; 10	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 2 days prior to compound washout followed by compound redosing and measured after 2 days by XTT assay	[PMID: 30594676]
HepG2 2.2.15	CC₅₀	50.4 μM Compound: II-8c; NZ-4	Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by MTT assay	[PMID: 32712535]
HepG2 2.2.15	CC₅₀	51.47 μM Compound: NZ-4	Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by CCK-8 assay	[PMID: 27484509]
HepG2 2.2.15	CC₅₀	59.2 μM Compound: II-8c; NZ-4	Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay Cytotoxicity against human HepG2.2.15 cells assessed as reduction in cell viability incubated for 4 days prior to compound washout followed by compound addition and measured after 4 days by CCK8 assay	[PMID: 32712535]
HepG2 2.2.15	IC₅₀	50.4 μM Compound: NZ-4	Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay Cytotoxicity against human HepG2.2.15 cells assessed as decrease in cell viability after 8 days by MTT assay	[PMID: 27484509]

In Vitro

Isothiafludine inhibits HBV DNA replication, with an IC₅₀ of 1.33 μM^[1].
Isothiafludine (8 days) shows an IC₅₀ (50% cytotoxicity) of 50.4 μM against HepG2.2.15 cells^[1].
Isothiafludine (1.25-20 μM, 48 h) also inhibits the replication of 3TC/ETV-dual-resistant and ADV-resistant HBV mutants in virus transfected Huh7 cells^[1].
Isothiafludine (10-20 μM, 8 days) decreases the levels of encapsidated HBV pgRNA in HepG2.2.15 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Isothiafludine (p.o., 25-100 mg/kg, for 15 days) inhibits DHBV DNA replication in a DHBV-infected duck model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

DHBV-infected duck model^[2]
Dosage:

25-100 mg/kg
Administration:

p.o., for 15 days
Result:

Inhibited DHBV DNA in the sera on day 15.

Chemical Information

CAS. Nr. 960527-22-4
Appearance Solid
Molecular Weight 375.48
Formel C₁₈H₁₈FN₃OS₂
Color White to off-white
SMILES

O=C(C1=C(CC(C)C)SC(C2=NC=CS2)=N1)NCC3=CC=C(F)C=C3
Synonyms

NZ-4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Yang L, et al. Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation. Acta Pharmacol Sin. 2014 Mar;35(3):410-8. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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Biologische Aktivität
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Isothiafludine

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Isothiafludine Related Classifications

HY-111003 Related Classifications