Kalimantacin A
Kalimantacin A is an Antibiotic. Kalimantacin A is produced by Alcaligenes sp. YL-02632S. Kalimantacin A inhibits bacterial fatty acid biosynthesis. Kalimantacin A exerts selective antibacterial activity against staphylococci, including multidrug-resistant Staphylococcus aureus and Staphylococcus epidermidis. Kalimantacin A shows no activity against most Gram-negative bacteria and fungi. Kalimantacin A exhibits anticancer activity against leukemia and cervical cancer. Kalimantacin A can be used in studies related to staphylococcal infections.
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- CAS. Nr.: 174513-95-2
- Formel: C30H48N2O7
- Molecular Weight:548.71
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
Microbial Metabolite |
In Vitro
Kalimantacin A potently inhibits the growth of Gram-positive bacteria, including MRSA[2].
Kalimantacin A (overnight treatment) potently inhibits the growth of Staphylococcus aureus (including MRSA) and Staphylococcus epidermidis (including MRSE) with an MIC of 0.2 μg/mL; it exhibits only weak activity against some Gram-negative bacteria, and shows no activity against Bacillus subtilis and Pseudomonas aeruginosa[3].
Kalimantacin A (72 h) exhibits cytotoxicity against P388 mouse leukemia cells (IC50 = 35 μg/mL) and HeLa S3 cells (IC50 = 50 μg/mL) after 72 h of incubation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 174513-95-2
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Molecular Weight 548.71
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Formel C30H48N2O7
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SMILES
O=C(O)/C=C(C)/CC(C)CC(CC/C=C/C=C/CC(C)CC(CC(O)CNC(C(C)C(OC(N)=O)C)=O)=O)=C
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Structure Classification
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Initial Source
Alcaligenes sp.
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Tokunaga T, et al. Kalimantacin A, B, and C, novel antibiotics produced by Alcaligenes sp. YL-02632S. II. Physico-chemical properties and structure elucidation. J Antibiot (Tokyo). 1996 Feb;49(2):140-4. [Content Brief]
[2]. Thistlethwaite IRG, et al. Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics. Chem Sci. 2017 Sep 1;8(9):6196-6201. [Content Brief]
[3]. Kamigiri K, et al. Kalimantacins A, B and C, novel antibiotics from Alcaligenes sp. YL-02632S. I. Taxonomy, fermentation, isolation and biological properties. J Antibiot (Tokyo). 1996 Feb;49(2):136-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Kalimantacin A Related Classifications
HY-142124 Related Classifications
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