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Art. -Nr.: HY-182411

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KRAS-IN-56

KRAS-IN-56 (Compound 18) is a KRAS inhibitor with an EC₅₀ of 33 μM. KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1. KRAS-IN-56 induces a decrease in p-ERK levels. KRAS-IN-56 can be used in research related to lung cancer.

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CAS. Nr.: 2375482-34-9
Formel: C₁₉H₁₉N₃O₂
Molecular Weight:321.37

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

KRAS-IN-56 Chemical Structure

CAS. Nr.: 2375482-34-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
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Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

K-RAS

33 μM (EC₅₀)

Alle Ras Isoform-spezifische Produkte anzeigen :

In Vitro

KRAS-IN-56 binds to the purified GCP-KRAS^G12D protein, with a measured K_d value of 20 μM via ITC^[1].
KRAS-IN-56 inhibits the interaction between GTP-KRAS and SOS1 in a biochemical assay, with an EC₅₀ of 33 μM^[1].
KRAS-IN-56 (10^-8-10^-4 M; 2 h) induces a dose-dependent decrease in pERK levels in NCI-H358 KRAS^G12C mutant lung cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2375482-34-9
Molecular Weight 321.37
Formel C₁₉H₁₉N₃O₂
SMILES

CN(C)CC1=C([C@@H]2C3=CC(O)=CC=C3C(N2)=O)C4=CC=CC=C4N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Kessler D, et al. Drugging an undruggable pocket on KRAS. Proc Natl Acad Sci U S A. 2019;116(32):15823-15829. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
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KRAS-IN-56

Alle Ras Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

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KRAS-IN-56 Related Classifications

HY-182411 Related Classifications