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Art. -Nr.: HY-114780

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Lactivicin

Lactivicin is a non-beta-lactam antibiotic showing beta-lactam action through binding to penicillin-binding protein (PBP). Lactivicin is moderately active against a wide range of Gram-negative bacteria and highly active against Gram-positive bacteria.

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CAS. Nr.: 107167-31-7
Formel: C₁₀H₁₂N₂O₇
Molecular Weight:272.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Lactivicin Chemical Structure

CAS. Nr.: 107167-31-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

Bacterial InfectionOthers

Bacterial Infection

Lactivicin exhibits moderate activity against most Gram-negative bacteria, high activity against Gram-positive and anaerobic bacteria, and significantly enhanced activity against β-lactam hypersensitive mutants E. coli PG-8 (MIC = 0.78 μg/mL) and P. aeruginosa C 141 (MIC = 0.2 μg/mL)^[2].
Lactivicin (100-1000 μg/mL) is highly susceptible to cephalosporinases and hydrolysed by multiple penicillinases, with full stability only against Bacillus cereus penicillinase^[2].
Lactivicin (0.5-10× MIC) lyses E. coli LD-2 cells and induces spheroplasts at 1× MIC, while causing growth stasis at concentrations above 5× MIC^[2].
Lactivicin (0.5-10× MIC) exhibits dose-dependent lytic activity against B. subtilis PCI 219, inducing filamentous cells at 1× MIC and strong lysis at concentrations above 5× MIC^[2].

Others

Lactivicin (0.5-20 μg/mL; 2 h) potently inhibits peptidoglycan synthesis in B. subtilis PCI 219 in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Gram Staining of Tissue Sections

Chemical Information

CAS. Nr. 107167-31-7
Molecular Weight 272.21
Formel C₁₀H₁₂N₂O₇
SMILES

O=C(O)C(N1OC[C@@H](C1=O)NC(C)=O)(O2)CCC2=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nozaki Y, et al. Lactivicin, a naturally occurring non-beta-lactam antibiotic having beta-lactam-like action: biological activities and mode of action. J Antibiot (Tokyo). 1989 Jan;42(1):84-93. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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