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Art. -Nr.: HY-157519

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LAH-1

LAH-1 is a c-Met inhibitor with oral activity and membrane permeability with an IC₅₀ of 49 nM. LAH-1 has anticancer activity and can induce apoptosis, migration, and invasion.

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CAS. Nr.: 3018150-68-7
Formel: C₂₇H₂₂F₂N₆O₅
Molecular Weight:548.50

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

LAH-1 Chemical Structure

CAS. Nr.: 3018150-68-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

LAH-1 is a c-Met inhibitor with oral activity and membrane permeability with an IC₅₀ of 49 nM. LAH-1 has anticancer activity and can induce apoptosis, migration, and invasion^[1].

IC₅₀ & Target

IC50: 49 nM (c-Met)^[1].

Chemical Information

CAS. Nr. 3018150-68-7
Molecular Weight 548.50
Formel C₂₇H₂₂F₂N₆O₅
SMILES

O=C(C(C(C)=C1)=NN(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=CC(NC(N5CC(O)C5)=O)=NC=C4)C(F)=C3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sima L,et al. Discovery of LAH-1 as potent c-Met inhibitor for the treatment of non-small cell lung cancer[J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2024, 39(1): 2286435. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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