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Art. -Nr.: HY-113456

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Leukotriene D4

Name: Leukotriene D4
Brand: MedChemExpress
SKU: HY-113456
Price: 180.00 USD
Availability: InStock
Rating: 5 (3 reviews)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability.
The product specifications provided below refer solely to the active content of Leukotriene D4.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 98.0%
CAS. Nr.: 73836-78-9
Formel: C₂₅H₄₀N₂O₆S
Molecular Weight:496.66

Speicherung:

Solution, -20°C, 2 years

Leukotriene D4 Chemical Structure

CAS. Nr.: 73836-78-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability^[1]^[2].
The product specifications provided below refer solely to the active content of Leukotriene D4.

IC₅₀ & Target

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	0.7 nM Compound: LTD4	Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins	[PMID: 23403082]
Sf9	IC₅₀	5.48 μM Compound: Leukotrien D4	TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells	[PMID: 11306690]

In Vivo

Leukotriene D4 (1.5, 3, 6, 12, 24 μg/paw; injected intradermally) causes edema and increases capillary permeability in a dose-related manner in mouse^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

21-24 g, Balb/c male mice^[2]
Dosage:

1.5, 3, 6, 12, 24 µg/paw
Administration:

Injected intradermally (10 µL was injected into the left hind paw)
Result:

Caused significant edematous response and dye extravasation at doses of 1.5-6 ~g/paw.

Related Protocols :

Transepithelial/transendothelial electrical resistance assay

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Chemical Information

CAS. Nr. 73836-78-9
Appearance Liquid
Molecular Weight 496.66
Formel C₂₅H₄₀N₂O₆S
Color Colorless to light yellow
SMILES

O=C(O)CNC([C@H](CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=C\C/C=C\CCCCC)N)=O
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Solution, -20°C, 2 years

Publications (3)

All Cell Migration/Invasion AssayELISABio/Physico-chemical Assay

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Journal Impact Factor

Anal Chem

Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]

2025 May 13;97(18):9827-9835. PMID: 40302637
Cancer Cell Int

DPEP2 suppresses metastasis via NF-κB-mediated epithelial-mesenchymal transition and M2 polarization in p53-loss non-small cell lung cancer. [Abstract]

2025 Nov 17;25(1):408. PMID: 41250029

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

The transwell and wound healing analyses of Vector/DPEP2 cells cultured with M2 CM or LTD4 (Leukotriene D4, 100 nM, 48 h).

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

ELISA detected the level of LTD4 in the medium of M2 cocultured with Vector/DPEP2 cells.

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Total LTD4 levels in lung metastases.
Res Sq

2026 Mar 11.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (467 KB)
- English - EN (467 KB)
- Français - FR (467 KB)
- Deutsch - DE (467 KB)
- Norwegian - NO (467 KB)
- Español - ES (467 KB)
- Swedish - SV (467 KB)
- Italian - IT (467 KB)
- Korean - KR (467 KB)
- Portuguese - PT (467 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Smith LJ, et al. The effect of inhaled leukotriene D4 in humans. Am Rev Respir Dis. 1985 Mar;131(3):368-72. [Content Brief]

[2]. Griswold DE, et al. Phlogistic activity of leukotriene D4 in the mouse. Inflammation. 1986 Mar;10(1):1-7. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Leukotriene D4

3 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
- Clinical Trial
Chemical Information
Publications (3)
Reinheit & Dokumentation
Verweise

1/16
1/16

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Customer Validation
The transwell and wound healing analyses of Vector/DPEP2 cells cultured with M2 CM or LTD4 (Leukotriene D4, 100 nM, 48 h).
1/16

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Customer Validation
ELISA detected the level of LTD4 in the medium of M2 cocultured with Vector/DPEP2 cells.
1/16

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Customer Validation
Total LTD4 levels in lung metastases.

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Leukotriene D4

Publications Citing Use of MedChemExpress (MCE) Leukotriene D4

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen