Leukotriene D4
Based on 3 publication(s) in Google Scholar
Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.5%
- CAS. Nr.: 73836-78-9
- Formel: C25H40N2O6S
- Molecular Weight:496.66
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Speicherung:
Solution, -20°C, 2 years
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Publications Citing Use of MedChemExpress (MCE) Leukotriene D4
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Cell Migration/Invasion Assay
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ELISA
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Bio/Physico-chemical Assay
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
Beschreibung
IC50 & Target
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Human Endogenous Metabolite |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| CHO-K1 | IC50 |
0.7 nM
Compound: LTD4
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Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins
Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins
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[PMID: 23403082] |
| Sf9 | IC50 |
5.48 μM
Compound: Leukotrien D4
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TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells
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[PMID: 11306690] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:21-24 g, Balb/c male mice[2]
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Dosage:1.5, 3, 6, 12, 24 µg/paw
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Administration:Injected intradermally (10 µL was injected into the left hind paw)
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Result:Caused significant edematous response and dye extravasation at doses of 1.5-6 ~g/paw.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 73836-78-9
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Appearance Liquid
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Molecular Weight 496.66
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Formel C25H40N2O6S
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Color Colorless to light yellow
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SMILES
O=C(O)CNC([C@H](CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=C\C/C=C\CCCCC)N)=O
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Solution, -20°C, 2 years
Publications (3)
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Journal Impact Factor
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Most Recent
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Anal Chem
Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]2025 May 13;97(18):9827-9835. PMID: 40302637 -
Cancer Cell Int
DPEP2 suppresses metastasis via NF-κB-mediated epithelial-mesenchymal transition and M2 polarization in p53-loss non-small cell lung cancer. [Abstract]2025 Nov 17;25(1):408. PMID: 41250029
Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]
The transwell and wound healing analyses of Vector/DPEP2 cells cultured with M2 CM or LTD4 (Leukotriene D4, 100 nM, 48 h).
Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]
ELISA detected the level of LTD4 in the medium of M2 cocultured with Vector/DPEP2 cells.
Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]
Total LTD4 levels in lung metastases.
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Protokoll
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Transepithelial/transendothelial electrical resistance assay
TEER measures electrical resistance across epithelial or endothelial monolayers cultured on permeable supports, and the readout reflects ionic conductance through the cell barrier, especially the paracellular pathway regulated by junctional integrity. TEER can be measured without destroying the monolayer and is commonly used before or during transport, permeability, barrier-disruption, and barrier-maturation experiments. TEER values are influenced by biological maturation and technical conditions; reported factors include temperature, medium formulation, passage number, electrode geometry, membrane properties, and junctional length during early monolayer maturation. Therefore, TEER should be interpreted with blank-insert subtraction, area normalization, repeated readings, and, when possible, orthogonal barrier readouts such as FITC-dextran flux or tight-junction staining.
Reinheit & Dokumentation
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Data Sheet (267 KB)
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Handling Instructions (2659 KB)
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Leukotriene D4 Related Classifications
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