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Art. -Nr.: HY-161417

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LIMK-IN-2

LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity.

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CAS. Nr.: 2747216-27-7
Formel: C₂₈H₂₇N₅O₂
Molecular Weight:465.55

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

LIMK-IN-2 Chemical Structure

CAS. Nr.: 2747216-27-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity^[1].

Alle LIM Kinase (LIMK) Isoform-spezifische Produkte anzeigen :

LIMK1
LIMK2

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	EC₅₀	>25 μM Compound: 52	Cytotoxicity against human skin fibroblast cells assessed as inhibition of cell growth measured after 48 hrs by Hoechst 33342 staining based analysis Cytotoxicity against human skin fibroblast cells assessed as inhibition of cell growth measured after 48 hrs by Hoechst 33342 staining based analysis	[PMID: 38669909]
HeLa	EC₅₀	26 μM Compound: 52	Cytotoxicity against human HeLa cells assessed as induction of cell death measured after 48 hrs by celltiter glo luminescent cell viability assay Cytotoxicity against human HeLa cells assessed as induction of cell death measured after 48 hrs by celltiter glo luminescent cell viability assay	[PMID: 38669909]
KHOS/NP	IC₅₀	6.2 μM Compound: 52	Cytotoxicity against human KHOS/NP cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis Cytotoxicity against human KHOS/NP cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis	[PMID: 38669909]
U2OS	IC₅₀	9.5 μM Compound: 52	Cytotoxicity against human U2OS cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter Aqueous One Solution Cell Proliferation Assay Cytotoxicity against human U2OS cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter Aqueous One Solution Cell Proliferation Assay	[PMID: 38669909]

Chemical Information

CAS. Nr. 2747216-27-7
Molecular Weight 465.55
Formel C₂₈H₂₇N₅O₂
SMILES

COC1=CC=CC(C2=CC(NC(N3CCC(C4=C5C(NC=C5C6CC6)=NC=N4)=CC3)=O)=CC=C2)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Champiré A, et al. Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization. Eur J Med Chem. Published online April 9, 2024. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
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Chemical Information
Reinheit & Dokumentation
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LIMK-IN-2

Alle LIM Kinase (LIMK) Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

LIMK-IN-2 Related Classifications

HY-161417 Related Classifications