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United States

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Art. -Nr.: HY-P992539

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LP-005

LP-005 is a bifunctional anti-C5 antibody fusion protein with pH-dependent C5 binding properties. LP-005 can simultaneously inhibit activation of the terminal complement pathway and the alternative pathway. LP-005 can be used for research on paroxysmal nocturnal hemoglobinuria (PNH).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

LP-005 Chemical Structure

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Species Reactivity
- In Vitro
- In Vivo
- Target
- Conjugated
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Species Reactivity

Human

In Vitro

LP-005 binds human C5 with pH-dependent kinetics, with a K_D of 6.70 × 10^-10 M at pH 7.4 and 2.45 × 10^-9 M at pH 6.0^[1].
LP-005 inhibits antibody-sensitized sheep erythrocyte hemolysis in 1% NHS with an IC₅₀ of 0.41 nM^[1].
LP-005 (20% ABO-compatible serum; pH 7.3) inhibits AP-induced hemolysis of CD59-deficient PNH erythrocytes by > 70%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LP-005 (intravenous infusion) can elevate hemoglobin levels and reduce LDH^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Target

C5 & C3b

Conjugated

Unconjugated

Anwendung

ELISA, FACS, Functional assay

Chemical Information

SMILES

[LP-005]
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Cheng L, et al. A Novel pH Dependent C5 Monoclonal Antibody with Better Developability. Blood. 2020;136(Supplement 1):11-12.

[2]. He G, et al. LP-005, a bifunctional C5 antibody fusion protein, efficacy and safety in PNH patients with active hemolysis: Updated results from a Phase 2 study at 12/24 weeks. Blood. 2025;146(Supplement 1):983.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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