LP-935001
LP-935001 is a Notum carboxylesterase inhibitor with an IC50 of 0.4 nM.LP-935001 prevents palmitoleate group removal from Wnt proteins, restores Wnt/β-catenin signaling.LP-935001 enhances cortical bone thickness in rodent models.LP-935001 can be used for the research of bone loss/nonvertebral fractures.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1875037-24-3
- Formel: C13H8ClFO2S
- Molecular Weight:282.72
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
LP-935001 potently inhibits human Notum carboxylesterase activity in a cell-free biochemical assay with an IC50 of 0.4 nM[1].
LP-935001 restores Wnt/β-catenin signaling in a cell-based reporter assay in the presence of Notum with an EC50 of 12 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1875037-24-3
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Molecular Weight 282.72
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Formel C13H8ClFO2S
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SMILES
O=C(C1=CC2=C(C3=C(CC2)C(Cl)=CC(F)=C3)S1)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
LP-935001 Related Classifications
HY-182632 Related Classifications
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