Art. -Nr.: HY-121584

Lycoperodine-1

(Synonyms: Cyclomethyltryptophan)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

Lycoperodine-1 (Cyclomethyltryptophan) is an active product that can be isolated from tomato fruits (Lycopersicon sculentum). Lycoperodine-1 act as an agonist of Ca²⁺ sensing receptors (CaSR).

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Reinheit: 99.82%
CAS. Nr.: 42438-90-4
Formel: C₁₂H₁₂N₂O₂
Molecular Weight:216.24

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Lycoperodine-1 Chemical Structure

CAS. Nr.: 42438-90-4

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	IC₅₀	3175.81 nM Compound: THCA	Inhibition of platelet-activating factor-induced platelet aggregation in pig blood Inhibition of platelet-activating factor-induced platelet aggregation in pig blood	[PMID: 18835178]
Platelet	IC₅₀	3289.1 nM Compound: THCA	Inhibition of thrombin-induced platelet aggregation in pig blood Inhibition of thrombin-induced platelet aggregation in pig blood	[PMID: 18835178]
Platelet	IC₅₀	3320.42 nM Compound: THCA	Inhibition of adenosine diphosphate-induced platelet aggregation in pig blood Inhibition of adenosine diphosphate-induced platelet aggregation in pig blood	[PMID: 18835178]
Platelet	IC₅₀	3429.33 nM Compound: THCA	Inhibition of arachidonic acid-induced platelet aggregation in pig blood Inhibition of arachidonic acid-induced platelet aggregation in pig blood	[PMID: 18835178]
Platelet	IC₅₀	701.01 nM Compound: 1, TCCA	Antiplatelet aggregation activity against ADP-induced pig platelet aggregation after 5 mins by aggregometer Antiplatelet aggregation activity against ADP-induced pig platelet aggregation after 5 mins by aggregometer	[PMID: 20329729]
Platelet	IC₅₀	752.28 nM Compound: 1, TCCA	Antiplatelet aggregation activity against platelet-activating factor-induced pig platelet aggregation after 5 mins by aggregometer Antiplatelet aggregation activity against platelet-activating factor-induced pig platelet aggregation after 5 mins by aggregometer	[PMID: 20329729]
Platelet	IC₅₀	866.14 nM Compound: 1, TCCA	Antiplatelet aggregation activity against arachidonic acid-induced pig platelet aggregation after 5 mins by aggregometer Antiplatelet aggregation activity against arachidonic acid-induced pig platelet aggregation after 5 mins by aggregometer	[PMID: 20329729]
Platelet	IC₅₀	981.52 nM Compound: 1, TCCA	Antiplatelet aggregation activity against thrombin-induced pig platelet aggregation after 5 mins by aggregometer Antiplatelet aggregation activity against thrombin-induced pig platelet aggregation after 5 mins by aggregometer	[PMID: 20329729]

Chemical Information

CAS. Nr. 42438-90-4
Appearance Solid
Molecular Weight 216.24
Formel C₁₂H₁₂N₂O₂
Color White to off-white
SMILES

O=C(O)[C@@H]1CC2=C(NC3=C2C=CC=C3)CN1
Synonyms

Cyclomethyltryptophan
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

J Agric Food Chem

Bromelain Alleviates Sleep Deprivation-Induced Intestinal Injury via TRPA1/5-HT Axis. [Abstract]

2025 Jul 23;73(29):18153-18164. PMID: 40662381

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 40 mg/mL (184.98 mM; ultrasonic and adjust pH to 9 with 1 M NaOH; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

1 M NaOH : 5 mg/mL (23.12 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.6245 mL

23.1225 mL

46.2449 mL

5 mM

0.9249 mL

4.6245 mL

9.2490 mL

10 mM

0.4624 mL

2.3122 mL

4.6245 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 4 mg/mL (18.50 mM); Clear solution

This protocol yields a clear solution of ≥ 4 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (40.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 4 mg/mL (18.50 mM); Clear solution

This protocol yields a clear solution of ≥ 4 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (40.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Shoji Yahara, et al. Steroidal Alkaloid Glycosides from Tomato (Lycopersicon esculentum). J Nat Prod. 2004 Mar;67(3):500-2. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
1 M NaOH / DMSO	1 mM	4.6245 mL	23.1225 mL	46.2449 mL	115.6123 mL
	5 mM	0.9249 mL	4.6245 mL	9.2490 mL	23.1225 mL
	10 mM	0.4624 mL	2.3122 mL	4.6245 mL	11.5612 mL
	15 mM	0.3083 mL	1.5415 mL	3.0830 mL	7.7075 mL
	20 mM	0.2312 mL	1.1561 mL	2.3122 mL	5.7806 mL
DMSO	25 mM	0.1850 mL	0.9249 mL	1.8498 mL	4.6245 mL
	30 mM	0.1541 mL	0.7707 mL	1.5415 mL	3.8537 mL
	40 mM	0.1156 mL	0.5781 mL	1.1561 mL	2.8903 mL
	50 mM	0.0925 mL	0.4624 mL	0.9249 mL	2.3122 mL
	60 mM	0.0771 mL	0.3854 mL	0.7707 mL	1.9269 mL
	80 mM	0.0578 mL	0.2890 mL	0.5781 mL	1.4452 mL
	100 mM	0.0462 mL	0.2312 mL	0.4624 mL	1.1561 mL

Keywords

Lycoperodine-1

1 Cited Publications

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Lycoperodine-1

MCE Bioactive Compound Library

Natural Product Library Plus

Publications Citing Use of MedChemExpress (MCE) Lycoperodine-1

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Lycoperodine-1

MCE Bioactive Compound Library

Natural Product Library Plus

Publications Citing Use of MedChemExpress (MCE) Lycoperodine-1

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Lycoperodine-1 Related Classifications

HY-121584 Related Classifications