MDOLL-0591
MDOLL-0591 is a selective CHIKV nsP3 macrodomain inhibitor and antiviral agent, with an IC50 of 10 μM against CHIKV nsP3. MDOLL-0591 inhibits the replication of CHIKV in cell culture systems. MDOLL-0591 is applicable to research related to Chikungunya virus infection.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C20H17N3O3S
- Molecular Weight:379.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| HEK-293T | EC50 |
0.5 μM
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Inhibition of CHIKV replication in human embryonic kidney HEK-293T cells assessed via NanoLuc luciferase activity at 20 hours post-infection with CHIKV-nLuc at MOI 0.05, with parallel ATP-based cell viability measurements confirming no significant cytotoxicity at tested concentrations.
Inhibition of CHIKV replication in human embryonic kidney HEK-293T cells assessed via NanoLuc luciferase activity at 20 hours post-infection with CHIKV-nLuc at MOI 0.05, with parallel ATP-based cell viability measurements confirming no significant cytotoxicity at tested concentrations.
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42531898 |
MDOLL-0591 (0.003-100 μM) potently inhibits ADP-ribosyl binding activity of the purified CHIKV nsP3 macrodomain with an IC50 of 10 μM[1].
MDOLL-0591 (12.5-50 μM; 16 h) inhibits CHIKV replication in BHK-21 cells in vitro in a concentration-dependent manner, reducing viral replication by nearly 70% at 50 μM without causing cytotoxicity[1].
MDOLL-0591 (12.5-50 μM; 20 h) potently inhibits CHIKV replication in HEK-293T cells with an EC50 of 0.5 μM, reducing viral replication by 97% at 50 μM without causing cytotoxicity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 379.43
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Formel C20H17N3O3S
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SMILES
O=C(N1C(C)=C(C)C2=C1C=CC3=CC=CC=C23)CSC4=NC(O)=CC(O)=N4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MDOLL-0591 Related Classifications
HY-187426 Related Classifications
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