MMV675968
MMV675968 is an inhibitor of Acinetobacter baumannii dihydrofolate reductase (AbDHFR) with an IC50 of 8.5 nM, and it exhibits selectivity against human DHFR. MMV675968 inhibits dihydrofolate reductase in Cryptosporidium, Plasmodium, and Escherichia coli, disrupting the thymidylate cycle and folate biosynthesis pathway. MMV675968 inhibits the growth of multiple A. baumannii strains, including clinical isolates and environmental isolates. MMV675968 is applicable to research related to A. baumannii infections.
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- CAS. Nr.: 159308-73-3
- Formel: C17H18ClN5O2
- Molecular Weight:359.81
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
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| HeLa | IC50 |
25 μM
Compound: 48; MMV675968
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by resazurin dye based fluorescence assay
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[PMID: 30647879] |
MMV675968 selectively inhibits A. baumannii DHFR but not human DHFR, with an IC50 of 8.5 nM against A. baumannii DHFR and an IC50 of 492.4 nM against human DHFR[1].
MMV675968 (0.6-10 μM; 18 h) inhibits the growth of Acinetobacter baumannii (A. baumannii) strains Mahidol, Naval-81, H72721 and 3-137, with IC50 values of 0.6-2.7 μM, IC90 values of 0.7-3.9 μM, and MIC values of 1.6-10 μM[1].
MMV675968 (10 μM; 18 h) inhibits the growth of E. coli PA414 surrogate cells expressing A. baumannii DHFR, but exerts no such effect on these cells expressing human DHFR[1].
MMV675968 (10 μM; 90 min) inhibits endogenous DHFR activity in Acinetobacter baumannii strains Mahidol, Naval-81, H72721, and 3-137[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 159308-73-3
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Molecular Weight 359.81
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Formel C17H18ClN5O2
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SMILES
ClC1=C2C(N)=NC(N)=NC2=CC=C1CNC3=CC(OC)=CC=C3OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MMV675968 Related Classifications
HY-182684 Related Classifications
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