mPEG2000-CM
Based on 1 Customer Validation
mPEG2000-CM (mPEG2000-COOH) is a carboxyl-terminated monomethoxy polyethylene glycol. mPEG2000-CM bears a reactive carboxyl group (-COOH) at its structural terminal site, which can form stable amide bonds with amino groups and ester bonds with hydroxyl groups. mPEG2000-CM binds to PCA-g-PCL copolymers via electrostatic interaction to form polyion complex micelles with a hydrophilic PEG surface, which enhances the stability of micelles in aqueous media. mPEG2000-CM can be used for drug delivery.
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- Reinheit: 99.96%
- Molecular Weight:2000 (Average)
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
mPEG-CM (MW 2000) (5 h at 150 °C) is successfully synthesized by reacting poly(ethylene glycol) methyl ether (Mn = 1900) with succinic anhydride at 150 °C for 5 h, followed by purification via double precipitation[1].
mPEG-CM (MW 2000) (0.2:1-1:1 feed molar ratio to PCA-g-PCL; 1 h mixed) conjugates with PCA-g-PCL via electrostatic interaction to form spherical polyion complex micelles, where higher mPEG-COOH to PCA-g-PCL molar ratios produce smaller micelles, and mPEG@PCA-g-PCL(1:1) micelles load paclitaxel with 7.8% drug loading and 78.6% encapsulation efficiency[1].
mPEG-CM (MW 2000) (0.2 g starch; 0.38 g mPEG-CM; 0.144 g EDC·HCl; 0.046 g DMAP in 15 mL DMSO; 48 h at 25 °C; 3 days (dialysis)) conjugated to soluble starch via EDC·HCl/DMAP coupling in DMSO at 25 °C for 48 h produces mPEGylated starch (mPEG-St) with a 76.4% yield[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 2000 (Average)
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Color White to off-white
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SMILES
COCCOCC(O)=O.[n]
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Synonyms
mPEG2000-COOH
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Reinheit & Dokumentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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