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Art. -Nr.: HY-D3152

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NRh-Cu

NRh-Cu is a highly sensitive near-infrared fluorescence turn-on indicator and Cu²⁺-selective probe (λ_ex=680 nm, λ_em=740 nm). When NRh-Cu interacts with Cu²⁺, it undergoes a structural transition from a non-fluorescent spirocyclic state to a fluorescent ring-opened state, which drives the enhancement of fluorescence emission. NRh-Cu can be used for Cu²⁺ imaging in live cells and in vivo.

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CAS. Nr.: 2361979-91-9
Formel: C₄₉H₅₅N₅O₃
Molecular Weight:761.99

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NRh-Cu Chemical Structure

CAS. Nr.: 2361979-91-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

In Vitro

NRh-Cu (10 μM) exhibits high selectivity for Cu²⁺ over a wide range of other metal ions in ethanol/H₂O solution, with a rapid fluorescence turn-on response reaching maximum intensity within 10 min; with a fluorescence-based detection limit of 0.95 ppb and absorption-based detection limit of 6.2 ppb^[1].
NRh-Cu (2-80 μM; 48 h) shows no significant cytotoxicity toward HeLa cells^[1].
NRh-Cu (10 μM; 1 h) exhibits good membrane permeability in HeLa cells and generates strong fluorescence in the presence of intracellular Cu²⁺^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HeLa cells
Concentration:

2-80 μM
Incubation Time:

48 h
Result:

Showed no significant difference in HeLa cell proliferation after incubation at concentrations from 2 to 80 μM for 48 h.

In Vivo

NRh-Cu (0.2 mL, 0.2 mg/mL; intravenous injection; single dose) binds to systemic Cu²⁺ in living mice, and the in vivo near-infrared fluorescence emission intensity increases significantly^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice (male, 4 weeks old, ~20 g)^[1]
Dosage:

0.2 mL, 0.2 mg/mL
Administration:

i.v.; single dose
Result:

Showed low fluorescence emission intensity when administered alone.
Showed a significant increase in fluorescence emission intensity when followed by systemic Cu²⁺ administration compared to the NRh-Cu-only group.

Chemical Information

CAS. Nr. 2361979-91-9
Molecular Weight 761.99
Formel C₄₉H₅₅N₅O₃
SMILES

CCN(C1=CC=C2C(OC3=C(C24C5=C(C(N4/N=C/C6=CC=C(C=C6O)N(CC)CC)=O)C=CC=C5)CCC/C3=C\C=C7N(C8=C(C/7(C)C)C=CC=C8)CC)=C1)CC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Xu Z, et al. Near-infrared fluorescent probe for selective detection of Cu2+ in living cells and in Vivo[J]. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 216: 404-410.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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