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Art. -Nr.: HY-153719

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NSC111552

NSC111552 is a potent SARS-CoV-2 NSP14 MTase inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC₅₀ of 5.1 μM.

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CAS. Nr.: 40420-48-2
Formel: C₁₂H₁₀O₃
Molecular Weight:202.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NSC111552 Chemical Structure

CAS. Nr.: 40420-48-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

NSC111552 is a potent SARS-CoV-2 NSP14 MTase inhibitor. NSC111552 inhibits the FL-NAH binding to the SARS-CoV-2 NSP14 MTase with an IC₅₀ of 5.1 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	5.24 μM Compound: 5	Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]
HS27	IC₅₀	9.87 μM Compound: 5	Cytotoxicity against human HS27 cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human HS27 cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]
Jurkat	IC₅₀	5.6 μM Compound: 5	Cytotoxicity against human Jurkat cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human Jurkat cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]
NALM-6	IC₅₀	5.09 μM Compound: 5	Cytotoxicity against human NALM6 cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human NALM6 cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]
Ramos	IC₅₀	0.75 μM Compound: 5	Cytotoxicity against human Ramos cells assessed as cell viability after 72 hrs by MTS assay Cytotoxicity against human Ramos cells assessed as cell viability after 72 hrs by MTS assay	[PMID: 24368029]

Chemical Information

CAS. Nr. 40420-48-2
Molecular Weight 202.21
Formel C₁₂H₁₀O₃
SMILES

O=C(C)C1=C(O)C2=C(C=CC=C2)C(O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Samrat SK, et al. A universal fluorescence polarization high throughput screening assay to target the SAM-binding sites of SARS-CoV-2 and other viral methyltransferases. Emerg Microbes Infect. 2023 Dec;12(1):2204164. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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