OB-1
Based on 1 Customer Validation
OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 99.40%
- CAS. Nr.: 300803-69-4
- Formel: C21H17N3O6
- Molecular Weight:407.38
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
Stomatin, STOML1, STOML2, STOML3[1]
In Vitro
OB-1 (3 h) reduces mechanotransduction currents in in N2a cells with an IC50 of 10 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
OB-1 (250 pmol per paw; s.c.; once) alleviates painful diabetic neuropathy in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57Bl/6N mice[1]
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Dosage:250-500 pmol per paw
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Administration:Subcutaneous injection, once
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Result:Over 40% of Aβ fibers (19/44) lacked a mechanosensitive receptive field, which was significantly different from that in vehicle-injected controls, where less than 7% (5/69 fibers) were found to be insensitive to mechanical stimuli. Reduced touch perception. Reversed tactile allodynia.
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Animal Model:Eight-week-old C57Bl/6 mice, Streptozotocin (HY-13753) model[1]
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Dosage:250 pmol per paw
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Administration:Subcutaneous injection, once
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Result:Substantially reversed the mechanical hypersensitivity 4 h after treatment.
Chemical Information
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CAS. Nr. 300803-69-4
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Appearance Solid
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Molecular Weight 407.38
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Formel C21H17N3O6
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Color White to off-white
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SMILES
O=C(C1=C(C2=CC=CC=C2)OC3=CC=C(OC4=C([N+]([O-])=O)N=CN4C)C=C13)OCC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 12.73 mg/mL (31.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4547 mL | 12.2736 mL | 24.5471 mL | 61.3678 mL |
| 5 mM | 0.4909 mL | 2.4547 mL | 4.9094 mL | 12.2736 mL | |
| 10 mM | 0.2455 mL | 1.2274 mL | 2.4547 mL | 6.1368 mL | |
| 15 mM | 0.1636 mL | 0.8182 mL | 1.6365 mL | 4.0912 mL | |
| 20 mM | 0.1227 mL | 0.6137 mL | 1.2274 mL | 3.0684 mL | |
| 25 mM | 0.0982 mL | 0.4909 mL | 0.9819 mL | 2.4547 mL | |
| 30 mM | 0.0818 mL | 0.4091 mL | 0.8182 mL | 2.0456 mL |
OB-1 Related Classifications
HY-122671 Related Classifications
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