OY-201
OY-201 is a potential and BBB-penetrated anti-ischemic stroke agent. OY-201 shows the good safety and neuroprotective activity in both in vitro and in vivo models.
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- CAS. Nr.: 2962943-05-9
- Formel: C25H33Cl2N
- Molecular Weight:418.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6J mice (Middle cerebral artery occlusion (MACO)-induced brain infarction model)[1]
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Dosage:10 mg/kg and 20 mg/kg
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Administration:IP
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Result:Attenuated brain injury of MCAO mice. 10 mg/kg of compound OY-201 reduced the infarcted volume to 13.3% and decreased the neurological severity scores to 1.5. Moreover, treatment with a higher dose of compound OY-201 (20 mg/kg) did not further improve the results, which showed an almost equivalent protective effect. OY-201 at 20 mg/kg significantly ameliorated the mortality of MCAO mice (35.7%) and the survival rate of compound OY-201 was 100% at the dose of 10 mg/kg.
Chemical Information
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CAS. Nr. 2962943-05-9
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Appearance Oil
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Molecular Weight 418.44
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Formel C25H33Cl2N
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SMILES
CCCCCCCCN([C@H]1CC[C@H](C2=CC=CC=C21)C3=CC=C(C(Cl)=C3)Cl)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 25 mg/mL (59.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
Verweise
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3898 mL | 11.9491 mL | 23.8983 mL | 59.7457 mL |
| 5 mM | 0.4780 mL | 2.3898 mL | 4.7797 mL | 11.9491 mL | |
| 10 mM | 0.2390 mL | 1.1949 mL | 2.3898 mL | 5.9746 mL | |
| 15 mM | 0.1593 mL | 0.7966 mL | 1.5932 mL | 3.9830 mL | |
| 20 mM | 0.1195 mL | 0.5975 mL | 1.1949 mL | 2.9873 mL | |
| 25 mM | 0.0956 mL | 0.4780 mL | 0.9559 mL | 2.3898 mL | |
| 30 mM | 0.0797 mL | 0.3983 mL | 0.7966 mL | 1.9915 mL | |
| 40 mM | 0.0597 mL | 0.2987 mL | 0.5975 mL | 1.4936 mL | |
| 50 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1949 mL |
OY-201 Related Classifications
HY-149253 Related Classifications
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