PCTR1
PCTR1 is a potent monocyte/macrophage agonist, regulating key anti-inflammatory and pro-resolving processes during bacterial infection. PCTR1 is a member of the protectin family of specialized pro-resolving mediators (SPMs).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1810710-59-8
- Formel: C32H47N3O9S
- Molecular Weight:649.80
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
PCTR1 is a peptide-containing lipid mediator. PCTR1 is temporally regulated during self-limited inflammation and promotes the resolution of bacterial infection. PCTR1 significantly decreases prostaglandin (PG)E2 (48%), PGD2 (64%), PGF2α (38%), and thromboxane B2 (40%). PCTR1 increases exudate macrophage levels, accelerates clearance of E. coli infection, decreases local inflammatory mediator production, and promotes resolution[1].
PCTR1 is an agonist of human keratinocyte migration and has unique structural features that impart this agonist activity. PCTR1 enhances human keratinocyte migration in a cAMP/PKA-dependent manner. Stimulation of keratinocytes with PCTR1 (10 nM; 15 minutes) significantly elevates levels of cAMP[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Primary human epidermal keratinocytes (HPEKp)
-
Concentration:0.1, 1, and 10 nM
-
Incubation Time:24 hours
-
Result:In comparison with untreated cells in which approximately 25% of the initially wounded area was covered by cells 24 hours after wounding, 10 nM significantly enhanced migration such that approximately 46% of the wound area was covered by cells at 24 hours after wounding.
PCTR1 (50?ng/mice) improves the survival rate in an LPS-induced acute inflammatory mouse model[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J wild-type male mice (8-10 weeks old, 22-25 g)[3]
-
Dosage:50 ng/mice
-
Administration:Administered via the tail vein 1 h after LPS (15 mg/kg) intraperitoneal injection. The survival rate was recorded every day for 7 days
-
Result:Compared with the LPS group, the survival rate was significantly higher in the LPS + PCTR1 group, indicating that PCTR1 markedly increases the survival rate.
Chemical Information
-
CAS. Nr. 1810710-59-8
-
Molecular Weight 649.80
-
Formel C32H47N3O9S
-
SMILES
CC/C=C\C[C@@H]([C@@H](/C=C/C=C/C=C\C/C=C\C/C=C\CCC(O)=O)SC[C@H](NC(CC[C@H](N)C(O)=O)=O)C(NCC(O)=O)=O)O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Sesquile Ramon, et al. The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation. Am J Pathol. 2016 Apr;186(4):962-73. [Content Brief]
[2]. Brian E Sansbury, et al. PCTR1 Enhances Repair and Bacterial Clearance in Skin Wounds. Am J Pathol. 2021 Jun;191(6):1049-1063. [Content Brief]
[3]. Yong-Jian Liu, et al. PCTR1 ameliorates lipopolysaccharide-induced acute inflammation and multiple organ damage via regulation of linoleic acid metabolism by promoting FADS1/FASDS2/ELOV2 expression and reducing PLA2 expression. Lab Invest. 2020 Jul;100(7):904-915. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PCTR1 Related Classifications
HY-125445 Related Classifications
Powered by Bioz